Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion

B. B. Chen, D. P. Nyhan, H. M. Goll, P. W. Clougherty, David Fehr, P. A. Murray

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Our objectives were 1) to investigate the extent to which the pulmonary vascular response to increasing cardiac index after a period of hypotension and hypoperfusion (defined as reperfusion) measured in conscious dogs is altered during pentobarbital sodium anesthesia, and 2) to determine whether pentobarbital anesthesia modifies autonomic nervous system (ANS) regulation of the pulmonary circulation during reperfusion. Base-line and reperfusion pulmonary vascular pressure-cardiac index (P/Q̇) plots were generated by stepwise inflation and deflation, respectively, of an inferior vena caval occluder to vary Q̇ in conscious and pentobarbital-anesthetized (30 mg/kg iv) dogs. During pentobarbital anesthesia, controlled ventilation (without positive end-expiratory pressure) allowed matching of systemic arterial and mixed venous blood gases to conscious values. Marked pulmonary vasoconstriction (P < 0.01) was observed during reperfusion in pentobarbital-anesthetized but not in conscious dogs. Both sympathetic α-adrenergic receptor block and total ANS ganglionic block attenuated, but did not abolish, the pulmonary vasoconstriction during reperfusion in pentobarbital-anesthetized dogs. Neither sympathetic β-adrenergic receptor block nor cholinergic receptor block enhanced the magnitude of the pulmonary vasoconstrictor response to reperfusion during pentobarbital anesthesia. Thus, in contrast to the conscious state, the pulmonary vascular response to reperfusion is characterized by active, non-flow-dependent pulmonary vasoconstriction during pentobarbital anesthesia. This response is primarily, but not exclusively, mediated by sympathetic α-adrenergic vasoconstriction and is not offset by either sympathetic β-adrenergic or cholinergic vasodilation. These results indicate, that, compared with the conscious state, pentobarbital anesthesia modifies pulmonary vasoregulation during reperfusion following hypotension and hypoperfusion.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume255
Issue number3
StatePublished - Jan 1 1988

Fingerprint

Pentobarbital
Reperfusion
Anesthesia
Lung
Vasoconstriction
Dogs
Blood Vessels
Autonomic Nervous System
Adrenergic Agents
Hypotension
Adrenergic Receptors
Venae Cavae
Pulmonary Circulation
Positive-Pressure Respiration
Economic Inflation
Cholinergic Receptors
Vasoconstrictor Agents
Vasodilation
Cholinergic Agents
Ventilation

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Chen, B. B. ; Nyhan, D. P. ; Goll, H. M. ; Clougherty, P. W. ; Fehr, David ; Murray, P. A. / Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion. In: American Journal of Physiology - Heart and Circulatory Physiology. 1988 ; Vol. 255, No. 3.
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Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion. / Chen, B. B.; Nyhan, D. P.; Goll, H. M.; Clougherty, P. W.; Fehr, David; Murray, P. A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 255, No. 3, 01.01.1988.

Research output: Contribution to journalArticle

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AU - Chen, B. B.

AU - Nyhan, D. P.

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N2 - Our objectives were 1) to investigate the extent to which the pulmonary vascular response to increasing cardiac index after a period of hypotension and hypoperfusion (defined as reperfusion) measured in conscious dogs is altered during pentobarbital sodium anesthesia, and 2) to determine whether pentobarbital anesthesia modifies autonomic nervous system (ANS) regulation of the pulmonary circulation during reperfusion. Base-line and reperfusion pulmonary vascular pressure-cardiac index (P/Q̇) plots were generated by stepwise inflation and deflation, respectively, of an inferior vena caval occluder to vary Q̇ in conscious and pentobarbital-anesthetized (30 mg/kg iv) dogs. During pentobarbital anesthesia, controlled ventilation (without positive end-expiratory pressure) allowed matching of systemic arterial and mixed venous blood gases to conscious values. Marked pulmonary vasoconstriction (P < 0.01) was observed during reperfusion in pentobarbital-anesthetized but not in conscious dogs. Both sympathetic α-adrenergic receptor block and total ANS ganglionic block attenuated, but did not abolish, the pulmonary vasoconstriction during reperfusion in pentobarbital-anesthetized dogs. Neither sympathetic β-adrenergic receptor block nor cholinergic receptor block enhanced the magnitude of the pulmonary vasoconstrictor response to reperfusion during pentobarbital anesthesia. Thus, in contrast to the conscious state, the pulmonary vascular response to reperfusion is characterized by active, non-flow-dependent pulmonary vasoconstriction during pentobarbital anesthesia. This response is primarily, but not exclusively, mediated by sympathetic α-adrenergic vasoconstriction and is not offset by either sympathetic β-adrenergic or cholinergic vasodilation. These results indicate, that, compared with the conscious state, pentobarbital anesthesia modifies pulmonary vasoregulation during reperfusion following hypotension and hypoperfusion.

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