Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Amos B. Smith, Carol M. Taylor, Stephen J. Benkovic, Ralph Hirschmann

Research output: Contribution to journalArticle

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Abstract

Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.

Original languageEnglish (US)
Pages (from-to)6853-6856
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number37
DOIs
StatePublished - Sep 12 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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