Peptide immunization elicits polyomavirus-specific MHC class Ib-restricted CD8 T cells in MHC class ia allogeneic mice

Amelia R. Hofstetter, Brian D. Evavold, Aron E. Lukacher

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2b haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2s and H-2g7 strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalViral Immunology
Volume26
Issue number1
DOIs
StatePublished - Feb 1 2013

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Virology

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