Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension

Said Jahanmir, Andrew Z. Hunsberger, Hooshang Heshmat, Michael J. Tomaszewski, James F. Walton, William Weiss, Branka Lukic, William E. Pae, Conrad M. Zapanta, Tigran Z. Khalapyan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The MiTiHeart (MiTiHeart Corporation, Gaithersburg, MD, USA) left ventricular assist device (LVAD), a third-generation blood pump, is being developed for destination therapy for adult heart failure patients of small to medium frame that are not being served by present pulsatile devices. The pump design is based on a novel, patented, hybrid passive/active magnetic bearing system with backup hydrodynamic thrust bearing and exhibits low power loss, low vibration, and low hemolysis. Performance of the titanium alloy prototype was evaluated in a series of in vitro tests with blood analogue to map out the performance envelop of the pump. The LVAD prototype was implanted in a calf animal model, and the in vivo pump performance was evaluated. The animal's native heart imparted a strong pulsatility to the flow rate. These tests confirmed the efficacy of the MiTiHeart LVAD design and confirmed that the pulsatility does not adversely affect the pump performance.

Original languageEnglish (US)
Pages (from-to)366-375
Number of pages10
JournalArtificial Organs
Volume32
Issue number5
DOIs
StatePublished - May 1 2008

Fingerprint

Left ventricular assist devices
Heart-Assist Devices
Suspensions
Pumps
Equipment Design
Hematologic Tests
Hydrodynamics
Vibration
Hemolysis
Titanium
Animals
Blood
Animal Models
Heart Failure
Thrust bearings
Magnetic bearings
Equipment and Supplies
Titanium alloys
Flow rate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Jahanmir, S., Hunsberger, A. Z., Heshmat, H., Tomaszewski, M. J., Walton, J. F., Weiss, W., ... Khalapyan, T. Z. (2008). Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension. Artificial Organs, 32(5), 366-375. https://doi.org/10.1111/j.1525-1594.2008.00559.x
Jahanmir, Said ; Hunsberger, Andrew Z. ; Heshmat, Hooshang ; Tomaszewski, Michael J. ; Walton, James F. ; Weiss, William ; Lukic, Branka ; Pae, William E. ; Zapanta, Conrad M. ; Khalapyan, Tigran Z. / Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension. In: Artificial Organs. 2008 ; Vol. 32, No. 5. pp. 366-375.
@article{e19d6e7e80774174bbf548780ff37368,
title = "Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension",
abstract = "The MiTiHeart (MiTiHeart Corporation, Gaithersburg, MD, USA) left ventricular assist device (LVAD), a third-generation blood pump, is being developed for destination therapy for adult heart failure patients of small to medium frame that are not being served by present pulsatile devices. The pump design is based on a novel, patented, hybrid passive/active magnetic bearing system with backup hydrodynamic thrust bearing and exhibits low power loss, low vibration, and low hemolysis. Performance of the titanium alloy prototype was evaluated in a series of in vitro tests with blood analogue to map out the performance envelop of the pump. The LVAD prototype was implanted in a calf animal model, and the in vivo pump performance was evaluated. The animal's native heart imparted a strong pulsatility to the flow rate. These tests confirmed the efficacy of the MiTiHeart LVAD design and confirmed that the pulsatility does not adversely affect the pump performance.",
author = "Said Jahanmir and Hunsberger, {Andrew Z.} and Hooshang Heshmat and Tomaszewski, {Michael J.} and Walton, {James F.} and William Weiss and Branka Lukic and Pae, {William E.} and Zapanta, {Conrad M.} and Khalapyan, {Tigran Z.}",
year = "2008",
month = "5",
day = "1",
doi = "10.1111/j.1525-1594.2008.00559.x",
language = "English (US)",
volume = "32",
pages = "366--375",
journal = "Artificial Organs",
issn = "0160-564X",
publisher = "Wiley-Blackwell",
number = "5",

}

Jahanmir, S, Hunsberger, AZ, Heshmat, H, Tomaszewski, MJ, Walton, JF, Weiss, W, Lukic, B, Pae, WE, Zapanta, CM & Khalapyan, TZ 2008, 'Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension', Artificial Organs, vol. 32, no. 5, pp. 366-375. https://doi.org/10.1111/j.1525-1594.2008.00559.x

Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension. / Jahanmir, Said; Hunsberger, Andrew Z.; Heshmat, Hooshang; Tomaszewski, Michael J.; Walton, James F.; Weiss, William; Lukic, Branka; Pae, William E.; Zapanta, Conrad M.; Khalapyan, Tigran Z.

In: Artificial Organs, Vol. 32, No. 5, 01.05.2008, p. 366-375.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Performance characterization of a rotary centrifugal left ventricular assist device with magnetic suspension

AU - Jahanmir, Said

AU - Hunsberger, Andrew Z.

AU - Heshmat, Hooshang

AU - Tomaszewski, Michael J.

AU - Walton, James F.

AU - Weiss, William

AU - Lukic, Branka

AU - Pae, William E.

AU - Zapanta, Conrad M.

AU - Khalapyan, Tigran Z.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - The MiTiHeart (MiTiHeart Corporation, Gaithersburg, MD, USA) left ventricular assist device (LVAD), a third-generation blood pump, is being developed for destination therapy for adult heart failure patients of small to medium frame that are not being served by present pulsatile devices. The pump design is based on a novel, patented, hybrid passive/active magnetic bearing system with backup hydrodynamic thrust bearing and exhibits low power loss, low vibration, and low hemolysis. Performance of the titanium alloy prototype was evaluated in a series of in vitro tests with blood analogue to map out the performance envelop of the pump. The LVAD prototype was implanted in a calf animal model, and the in vivo pump performance was evaluated. The animal's native heart imparted a strong pulsatility to the flow rate. These tests confirmed the efficacy of the MiTiHeart LVAD design and confirmed that the pulsatility does not adversely affect the pump performance.

AB - The MiTiHeart (MiTiHeart Corporation, Gaithersburg, MD, USA) left ventricular assist device (LVAD), a third-generation blood pump, is being developed for destination therapy for adult heart failure patients of small to medium frame that are not being served by present pulsatile devices. The pump design is based on a novel, patented, hybrid passive/active magnetic bearing system with backup hydrodynamic thrust bearing and exhibits low power loss, low vibration, and low hemolysis. Performance of the titanium alloy prototype was evaluated in a series of in vitro tests with blood analogue to map out the performance envelop of the pump. The LVAD prototype was implanted in a calf animal model, and the in vivo pump performance was evaluated. The animal's native heart imparted a strong pulsatility to the flow rate. These tests confirmed the efficacy of the MiTiHeart LVAD design and confirmed that the pulsatility does not adversely affect the pump performance.

UR - http://www.scopus.com/inward/record.url?scp=43549094191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43549094191&partnerID=8YFLogxK

U2 - 10.1111/j.1525-1594.2008.00559.x

DO - 10.1111/j.1525-1594.2008.00559.x

M3 - Article

C2 - 18471166

AN - SCOPUS:43549094191

VL - 32

SP - 366

EP - 375

JO - Artificial Organs

JF - Artificial Organs

SN - 0160-564X

IS - 5

ER -