TY - JOUR
T1 - Peri-adolescent asthma
T2 - Acute impacts on innate immune response, corticosterone, and microglia in mice
AU - Caulfield, Jasmine I.
AU - Schopf, Kerri J.
AU - Cavigelli, Sonia A.
N1 - Funding Information:
This work was supported by NIH Grant 1R21MH092667 (SAC), T32GM108563 (to support JIC), Pennsylvania State University salary release research funds (SAC), the Huck Graduate Research Innovation Award (JIC), and the Biobehavioral Health Dissertation Award (JIC).
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.
AB - Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.
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U2 - 10.1016/j.jneuroim.2020.577450
DO - 10.1016/j.jneuroim.2020.577450
M3 - Article
C2 - 33285450
AN - SCOPUS:85097228861
SN - 0165-5728
VL - 350
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
M1 - 577450
ER -