Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice

Jasmine I. Caulfield, Michael J. Caruso, Kerry C. Michael, Rebecca A. Bourne, Nicole R. Chirichella, Laura C. Klein, Timothy Craig, Robert H. Bonneau, Avery August, Sonia A. Cavigelli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Human and animal studies have shown that physical challenges and stressors during adolescence can have significant influences on behavioral and neurobiological development associated with internalizing disorders such as anxiety and depression. Given the prevalence of asthma during adolescence and increased rates of internalizing disorders in humans with asthma, we used a mouse model to test if and which symptoms of adolescent allergic asthma (airway inflammation or labored breathing) cause adult anxiety- and depression-related behavior and brain function. To mimic symptoms of allergic asthma in young BALB/cJ mice (postnatal days [P] 7–57; N = 98), we induced lung inflammation with repeated intranasal administration of house dust mite extract (most common aeroallergen for humans) and bronchoconstriction with aerosolized methacholine (non-selective muscarinic receptor agonist). Three experimental groups, in addition to a control group, included: (1) “Airway inflammation only”, allergen exposure 3 times/week, (2) “Labored breathing only”, methacholine exposure once/week, and (3) “Airway inflammation + Labored breathing”, allergen and methacholine exposure. Compared to controls, mice that experienced methacholine-induced labored breathing during adolescence displayed a ∼20% decrease in time on open arms of the elevated plus maze in early adulthood (P60), a ∼30% decrease in brainstem serotonin transporter (SERT) mRNA expression and a ∼50% increase in hippocampal serotonin receptor 1a (5Htr1a) and corticotropin releasing hormone receptor 1 (Crhr1) expression in adulthood (P75). This is the first evidence that experimentally-induced clinical symptoms of adolescent asthma alter adult anxiety-related behavior and brain function several weeks after completion of asthma manipulations.

Original languageEnglish (US)
Pages (from-to)244-255
Number of pages12
JournalBehavioural Brain Research
Volume326
DOIs
StatePublished - May 30 2017

Fingerprint

Asthma
Anxiety
Methacholine Chloride
Respiration
Inflammation
Allergens
Depression
Corticotropin-Releasing Hormone Receptors
Intranasal Administration
Muscarinic Agonists
Pyroglyphidae
Serotonin Plasma Membrane Transport Proteins
Receptor, Serotonin, 5-HT1A
Bronchoconstriction
Brain
Muscarinic Receptors
Brain Stem
Pneumonia
Control Groups
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Caulfield, Jasmine I. ; Caruso, Michael J. ; Michael, Kerry C. ; Bourne, Rebecca A. ; Chirichella, Nicole R. ; Klein, Laura C. ; Craig, Timothy ; Bonneau, Robert H. ; August, Avery ; Cavigelli, Sonia A. / Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice. In: Behavioural Brain Research. 2017 ; Vol. 326. pp. 244-255.
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Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice. / Caulfield, Jasmine I.; Caruso, Michael J.; Michael, Kerry C.; Bourne, Rebecca A.; Chirichella, Nicole R.; Klein, Laura C.; Craig, Timothy; Bonneau, Robert H.; August, Avery; Cavigelli, Sonia A.

In: Behavioural Brain Research, Vol. 326, 30.05.2017, p. 244-255.

Research output: Contribution to journalArticle

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AU - Caulfield, Jasmine I.

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AU - Cavigelli, Sonia A.

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