Perinatal exposure to low doses of dioxin can permanently impair human semen quality

Paolo Mocarelli, Pier Mario Gerthoux, Larry L. Needham, Donald G. Patterson, Giuseppe Limonta, Rosanna Falbo, Stefano Signorini, Maria Bertona, Carla Crespi, Cecilia Sarto, Paul K. Scott, Wayman E. Turner, Paolo Brambilla

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Background: In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality. Objective: We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones. Methods: We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples. R esults: The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02). C onclusions: In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalEnvironmental health perspectives
Volume119
Issue number5
DOIs
StatePublished - May 1 2011

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Dioxins
Semen Analysis
Breast
Spermatozoa
Mothers
Nuclear Family
Hormones
Follicle Stimulating Hormone
Serum
Italy
Accidents

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Mocarelli, P., Gerthoux, P. M., Needham, L. L., Patterson, D. G., Limonta, G., Falbo, R., ... Brambilla, P. (2011). Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environmental health perspectives, 119(5), 713-718. https://doi.org/10.1289/ehp.1002134
Mocarelli, Paolo ; Gerthoux, Pier Mario ; Needham, Larry L. ; Patterson, Donald G. ; Limonta, Giuseppe ; Falbo, Rosanna ; Signorini, Stefano ; Bertona, Maria ; Crespi, Carla ; Sarto, Cecilia ; Scott, Paul K. ; Turner, Wayman E. ; Brambilla, Paolo. / Perinatal exposure to low doses of dioxin can permanently impair human semen quality. In: Environmental health perspectives. 2011 ; Vol. 119, No. 5. pp. 713-718.
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abstract = "Background: In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality. Objective: We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones. Methods: We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples. R esults: The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2{\%}; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02). C onclusions: In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.",
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Mocarelli, P, Gerthoux, PM, Needham, LL, Patterson, DG, Limonta, G, Falbo, R, Signorini, S, Bertona, M, Crespi, C, Sarto, C, Scott, PK, Turner, WE & Brambilla, P 2011, 'Perinatal exposure to low doses of dioxin can permanently impair human semen quality', Environmental health perspectives, vol. 119, no. 5, pp. 713-718. https://doi.org/10.1289/ehp.1002134

Perinatal exposure to low doses of dioxin can permanently impair human semen quality. / Mocarelli, Paolo; Gerthoux, Pier Mario; Needham, Larry L.; Patterson, Donald G.; Limonta, Giuseppe; Falbo, Rosanna; Signorini, Stefano; Bertona, Maria; Crespi, Carla; Sarto, Cecilia; Scott, Paul K.; Turner, Wayman E.; Brambilla, Paolo.

In: Environmental health perspectives, Vol. 119, No. 5, 01.05.2011, p. 713-718.

Research output: Contribution to journalArticle

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T1 - Perinatal exposure to low doses of dioxin can permanently impair human semen quality

AU - Mocarelli, Paolo

AU - Gerthoux, Pier Mario

AU - Needham, Larry L.

AU - Patterson, Donald G.

AU - Limonta, Giuseppe

AU - Falbo, Rosanna

AU - Signorini, Stefano

AU - Bertona, Maria

AU - Crespi, Carla

AU - Sarto, Cecilia

AU - Scott, Paul K.

AU - Turner, Wayman E.

AU - Brambilla, Paolo

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Y1 - 2011/5/1

N2 - Background: In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality. Objective: We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones. Methods: We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples. R esults: The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02). C onclusions: In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.

AB - Background: In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality. Objective: We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones. Methods: We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples. R esults: The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02). C onclusions: In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.

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Mocarelli P, Gerthoux PM, Needham LL, Patterson DG, Limonta G, Falbo R et al. Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environmental health perspectives. 2011 May 1;119(5):713-718. https://doi.org/10.1289/ehp.1002134