Perinatal methadone exposure in rats

Effects on body and organ development

Patricia McLaughlin, Ian Zagon, William J. White

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effects of maternal methadone (5 mg/kg methadone-HCl) administration during gestation and/or lactation on gross body measurements, absolute organ weights, dry weights, and tissue water content were studied in 21-day-old Sprague-Dawley rats. Offspring perinatally exposed to methadone had significantly lower body weights, crown to rump lengths, tail lengths and head diameters. In contrast to age-control values, absolute organ weights of the adrenals, brain, heart, kidneys, liver, lungs, muscle, and testes were reduced in all drug-treated groups; the spleen, thymus, and ovaries of some methadone groups were also lighter in weight. Organ:body weight ratios revealed fewer significant differences than recorded for absolute weights. Dry weights and tissue water content of the kidneys, liver and muscle were affected in all drug-treated animals; other organs were markedly affected by at least one schedule of methadone administration. These results suggest that perinatal methadone exposure has detrimental effects on preweaning organ and body development that may be of long-term functional consequence to the animal.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalNeonatology
Volume34
Issue number1-2
DOIs
StatePublished - Jan 1 1978

Fingerprint

Methadone
Organ Size
Weights and Measures
Body Weight
Crown-Rump Length
Kidney
Muscles
Water
Liver
Lactation
Pharmaceutical Preparations
Thymus Gland
Sprague Dawley Rats
Tail
Testis
Ovary
Appointments and Schedules
Spleen
Mothers
Pregnancy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

@article{fb4c73793fd24fdbaf3ee5ce1dba38fd,
title = "Perinatal methadone exposure in rats: Effects on body and organ development",
abstract = "The effects of maternal methadone (5 mg/kg methadone-HCl) administration during gestation and/or lactation on gross body measurements, absolute organ weights, dry weights, and tissue water content were studied in 21-day-old Sprague-Dawley rats. Offspring perinatally exposed to methadone had significantly lower body weights, crown to rump lengths, tail lengths and head diameters. In contrast to age-control values, absolute organ weights of the adrenals, brain, heart, kidneys, liver, lungs, muscle, and testes were reduced in all drug-treated groups; the spleen, thymus, and ovaries of some methadone groups were also lighter in weight. Organ:body weight ratios revealed fewer significant differences than recorded for absolute weights. Dry weights and tissue water content of the kidneys, liver and muscle were affected in all drug-treated animals; other organs were markedly affected by at least one schedule of methadone administration. These results suggest that perinatal methadone exposure has detrimental effects on preweaning organ and body development that may be of long-term functional consequence to the animal.",
author = "Patricia McLaughlin and Ian Zagon and White, {William J.}",
year = "1978",
month = "1",
day = "1",
doi = "10.1159/000241104",
language = "English (US)",
volume = "34",
pages = "48--54",
journal = "Neonatology",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "1-2",

}

Perinatal methadone exposure in rats : Effects on body and organ development. / McLaughlin, Patricia; Zagon, Ian; White, William J.

In: Neonatology, Vol. 34, No. 1-2, 01.01.1978, p. 48-54.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perinatal methadone exposure in rats

T2 - Effects on body and organ development

AU - McLaughlin, Patricia

AU - Zagon, Ian

AU - White, William J.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - The effects of maternal methadone (5 mg/kg methadone-HCl) administration during gestation and/or lactation on gross body measurements, absolute organ weights, dry weights, and tissue water content were studied in 21-day-old Sprague-Dawley rats. Offspring perinatally exposed to methadone had significantly lower body weights, crown to rump lengths, tail lengths and head diameters. In contrast to age-control values, absolute organ weights of the adrenals, brain, heart, kidneys, liver, lungs, muscle, and testes were reduced in all drug-treated groups; the spleen, thymus, and ovaries of some methadone groups were also lighter in weight. Organ:body weight ratios revealed fewer significant differences than recorded for absolute weights. Dry weights and tissue water content of the kidneys, liver and muscle were affected in all drug-treated animals; other organs were markedly affected by at least one schedule of methadone administration. These results suggest that perinatal methadone exposure has detrimental effects on preweaning organ and body development that may be of long-term functional consequence to the animal.

AB - The effects of maternal methadone (5 mg/kg methadone-HCl) administration during gestation and/or lactation on gross body measurements, absolute organ weights, dry weights, and tissue water content were studied in 21-day-old Sprague-Dawley rats. Offspring perinatally exposed to methadone had significantly lower body weights, crown to rump lengths, tail lengths and head diameters. In contrast to age-control values, absolute organ weights of the adrenals, brain, heart, kidneys, liver, lungs, muscle, and testes were reduced in all drug-treated groups; the spleen, thymus, and ovaries of some methadone groups were also lighter in weight. Organ:body weight ratios revealed fewer significant differences than recorded for absolute weights. Dry weights and tissue water content of the kidneys, liver and muscle were affected in all drug-treated animals; other organs were markedly affected by at least one schedule of methadone administration. These results suggest that perinatal methadone exposure has detrimental effects on preweaning organ and body development that may be of long-term functional consequence to the animal.

UR - http://www.scopus.com/inward/record.url?scp=0017888404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017888404&partnerID=8YFLogxK

U2 - 10.1159/000241104

DO - 10.1159/000241104

M3 - Article

VL - 34

SP - 48

EP - 54

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 1-2

ER -