Perioperative circulating tumor cell detection: Current perspectives

Jussuf T. Kaifi, Guangfu Li, Gary Clawson, Eric T. Kimchi, Kevin F. Staveley-O'Carroll

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Primary cancer resections and in selected cases surgical metastasectomies significantly improve survival, however many patients develop recurrences. Circulating tumor cells (CTCs) function as an independent marker that could be used in the prognostication of different cancers. Sampling of blood and bone marrow compartments during cancer resections is a unique opportunity to increase individual tumor cell capture efficiency. This review will address the diagnostic and therapeutic potentials of perioperative tumor isolation and highlight the focus of future studies on characterization of single disseminated cancer cells to identify targets for molecular therapy and immune escape mechanisms.

Original languageEnglish (US)
Pages (from-to)859-869
Number of pages11
JournalCancer Biology and Therapy
Volume17
Issue number8
DOIs
StatePublished - Aug 2 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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