Peripheral nerve injury and myelination: Potential therapeutic strategies

Max Modrak, M. A.Hassan Talukder, Khatuna Gurgenashvili, Mark Noble, John C. Elfar

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Traumatic peripheral nerve injury represents a major clinical and public health problem that often leads to significant functional impairment and permanent disability. Despite modern diagnostic procedures and advanced microsurgical techniques, functional recovery after peripheral nerve repair is often unsatisfactory. Therefore, there is an unmet need for new therapeutic or adjunctive strategies to promote the functional recovery in nerve injury patients. In contrast to the central nervous system, Schwann cells in the peripheral nervous system play a pivotal role in several aspects of nerve repair such as degeneration, remyelination, and axonal growth. Several non-surgical approaches, including pharmacological, electrical, cell-based, and laser therapies, have been employed to promote myelination and enhance functional recovery after peripheral nerve injury. This review will succinctly discuss the potential therapeutic strategies in the context of myelination following peripheral neurotrauma.

Original languageEnglish (US)
Pages (from-to)780-795
Number of pages16
JournalJournal of Neuroscience Research
Volume98
Issue number5
DOIs
StatePublished - May 1 2020

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

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