Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner

Caitlin E. Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T. Postolache, Shannon L. Kelleher, Erika F.H. Saunders

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalPsychiatry Research
Volume255
DOIs
StatePublished - Sep 2017

Fingerprint

Neopterin
Bipolar Disorder
Zinc
Biomarkers
Depression
Acute-Phase Reaction
Mood Disorders
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Millett, Caitlin E. ; Mukherjee, Dahlia ; Reider, Aubrey ; Can, Adem ; Groer, Maureen ; Fuchs, Dietmar ; Postolache, Teodor T. ; Kelleher, Shannon L. ; Saunders, Erika F.H. / Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner. In: Psychiatry Research. 2017 ; Vol. 255. pp. 52-58.
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Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner. / Millett, Caitlin E.; Mukherjee, Dahlia; Reider, Aubrey; Can, Adem; Groer, Maureen; Fuchs, Dietmar; Postolache, Teodor T.; Kelleher, Shannon L.; Saunders, Erika F.H.

In: Psychiatry Research, Vol. 255, 09.2017, p. 52-58.

Research output: Contribution to journalArticle

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AU - Mukherjee, Dahlia

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AU - Can, Adem

AU - Groer, Maureen

AU - Fuchs, Dietmar

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AU - Kelleher, Shannon L.

AU - Saunders, Erika F.H.

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