Peritoneal loss of insulin-like growth factor-I and binding proteins in end-stage renal disease

Gamze Bereket, Jen Jar Lin, Abdullah Bereket, Charles H. Lang, Frederick J. Kaskel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The kinetics of peritoneal transport of insulin-like growth factor (IGF) system-related proteins during dialysis is not well characterized. We studied temporal changes in dialysate and serum concentrations of IGF-I and IGF-II as well as IGF binding protein (BP)-1, -2, and -3 in ten children with end-stage renal disease (ESRD) undergoing continuous cycling peritoneal dialysis (CCPD) during a 4-h peritoneal equilibration test (PET). Dialysate concentrations of IGF-I, IGF-II, and all three IGFBPs demonstrated a time-dependent increase during PET. Despite their transport, the serum concentrations of these proteins did not change significantly during the PET. Dialysate/serum ratios for IGF-I, IGF-II, and IGFBP-1, -2, and -3 were significantly increased at 2 h and increased further at 4 h, at which time values averaged 1.3 ± 0.2%, 3.1 ± 0.5%, 6.2 ± 1.0%, 2.4 ± 0.2%, and 1.3 ± 0.2% of serum levels, respectively. The transperitoneal clearance (μl/min per 1.73 m2) of the three IGFBPs was inversely related to both their molecular weight and plasma concentration. However, peritoneal clearance of IGF-I and -II was similar to that of the larger and more-abundant IGFBP-3. Mass transfer rates (μg/h per 1.73 m2) for the IGFs and their binding proteins were directly proportional to their prevailing plasma concentration. Based on estimates of mass transfer, only a small molar excess of IGFBPs was removed from the circulation relative to the combined molar concentration of IGF-I and IGF-II. Hence, it seems unlikely that any beneficial effect of CCPD on growth in children with ESRD is mediated via a preferential loss of IGFBPs into the dialysate fluid.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalPediatric Nephrology
Volume12
Issue number7
DOIs
StatePublished - Sep 1 1998

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Chronic Kidney Failure
Dialysis Solutions
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 1
Peritoneal Dialysis
Serum
Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Blood Proteins
Dialysis
Molecular Weight
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Bereket, Gamze ; Lin, Jen Jar ; Bereket, Abdullah ; Lang, Charles H. ; Kaskel, Frederick J. / Peritoneal loss of insulin-like growth factor-I and binding proteins in end-stage renal disease. In: Pediatric Nephrology. 1998 ; Vol. 12, No. 7. pp. 581-588.
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abstract = "The kinetics of peritoneal transport of insulin-like growth factor (IGF) system-related proteins during dialysis is not well characterized. We studied temporal changes in dialysate and serum concentrations of IGF-I and IGF-II as well as IGF binding protein (BP)-1, -2, and -3 in ten children with end-stage renal disease (ESRD) undergoing continuous cycling peritoneal dialysis (CCPD) during a 4-h peritoneal equilibration test (PET). Dialysate concentrations of IGF-I, IGF-II, and all three IGFBPs demonstrated a time-dependent increase during PET. Despite their transport, the serum concentrations of these proteins did not change significantly during the PET. Dialysate/serum ratios for IGF-I, IGF-II, and IGFBP-1, -2, and -3 were significantly increased at 2 h and increased further at 4 h, at which time values averaged 1.3 ± 0.2{\%}, 3.1 ± 0.5{\%}, 6.2 ± 1.0{\%}, 2.4 ± 0.2{\%}, and 1.3 ± 0.2{\%} of serum levels, respectively. The transperitoneal clearance (μl/min per 1.73 m2) of the three IGFBPs was inversely related to both their molecular weight and plasma concentration. However, peritoneal clearance of IGF-I and -II was similar to that of the larger and more-abundant IGFBP-3. Mass transfer rates (μg/h per 1.73 m2) for the IGFs and their binding proteins were directly proportional to their prevailing plasma concentration. Based on estimates of mass transfer, only a small molar excess of IGFBPs was removed from the circulation relative to the combined molar concentration of IGF-I and IGF-II. Hence, it seems unlikely that any beneficial effect of CCPD on growth in children with ESRD is mediated via a preferential loss of IGFBPs into the dialysate fluid.",
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Peritoneal loss of insulin-like growth factor-I and binding proteins in end-stage renal disease. / Bereket, Gamze; Lin, Jen Jar; Bereket, Abdullah; Lang, Charles H.; Kaskel, Frederick J.

In: Pediatric Nephrology, Vol. 12, No. 7, 01.09.1998, p. 581-588.

Research output: Contribution to journalArticle

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T1 - Peritoneal loss of insulin-like growth factor-I and binding proteins in end-stage renal disease

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AU - Lin, Jen Jar

AU - Bereket, Abdullah

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AU - Kaskel, Frederick J.

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AB - The kinetics of peritoneal transport of insulin-like growth factor (IGF) system-related proteins during dialysis is not well characterized. We studied temporal changes in dialysate and serum concentrations of IGF-I and IGF-II as well as IGF binding protein (BP)-1, -2, and -3 in ten children with end-stage renal disease (ESRD) undergoing continuous cycling peritoneal dialysis (CCPD) during a 4-h peritoneal equilibration test (PET). Dialysate concentrations of IGF-I, IGF-II, and all three IGFBPs demonstrated a time-dependent increase during PET. Despite their transport, the serum concentrations of these proteins did not change significantly during the PET. Dialysate/serum ratios for IGF-I, IGF-II, and IGFBP-1, -2, and -3 were significantly increased at 2 h and increased further at 4 h, at which time values averaged 1.3 ± 0.2%, 3.1 ± 0.5%, 6.2 ± 1.0%, 2.4 ± 0.2%, and 1.3 ± 0.2% of serum levels, respectively. The transperitoneal clearance (μl/min per 1.73 m2) of the three IGFBPs was inversely related to both their molecular weight and plasma concentration. However, peritoneal clearance of IGF-I and -II was similar to that of the larger and more-abundant IGFBP-3. Mass transfer rates (μg/h per 1.73 m2) for the IGFs and their binding proteins were directly proportional to their prevailing plasma concentration. Based on estimates of mass transfer, only a small molar excess of IGFBPs was removed from the circulation relative to the combined molar concentration of IGF-I and IGF-II. Hence, it seems unlikely that any beneficial effect of CCPD on growth in children with ESRD is mediated via a preferential loss of IGFBPs into the dialysate fluid.

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