Peroxisomes are ubiquitous subcellular organelles. Peroxisomal disorders may be divided into disorders of peroxisome biogenesis and single-enzyme disorders. Nearly all of these disorders are expressed in the nervous system. The most common disorder of the group is X-linked adrenoleukodystrophy, which may develop in either childhood or adulthood with various neurologic manifestations. In contrast are the severe biogenesis disorders that are multisystem and may affect neuronal migration with resultant developmental abnormalities, seizures, and progressive demyelination. The diagnosis of these disorders results on the understanding of the biochemical abnormalities and they may reliably diagnosed by biochemical measures or DNA analysis.
|Original language||English (US)|
|Title of host publication||Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease|
|Subtitle of host publication||Fifth Edition|
|Number of pages||12|
|State||Published - Nov 13 2014|
All Science Journal Classification (ASJC) codes