Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis

Fred S. Harman, Christopher J. Nicol, Holly E. Marin, Jerrold M. Ward, Frank J. Gonzalez, Jeffrey M. Peters

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptor-δ (PPAR-δ; also known as PPAR-β) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-δ in colon carcinogenesis using PPAR-δ-deficient (Ppard-/-) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-δ. In contrast to previous reports suggesting that activation of PPAR-δ potentiates colon polyp formation, here we show that PPAR-δ attenuates colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)481-483
Number of pages3
JournalNature Medicine
Volume10
Issue number5
DOIs
StatePublished - May 1 2004

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Peroxisome Proliferator-Activated Receptors
Colon
Carcinogenesis
Polyps
Colonic Neoplasms
Tumors
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Harman, F. S., Nicol, C. J., Marin, H. E., Ward, J. M., Gonzalez, F. J., & Peters, J. M. (2004). Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis. Nature Medicine, 10(5), 481-483. https://doi.org/10.1038/nm1026
Harman, Fred S. ; Nicol, Christopher J. ; Marin, Holly E. ; Ward, Jerrold M. ; Gonzalez, Frank J. ; Peters, Jeffrey M. / Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis. In: Nature Medicine. 2004 ; Vol. 10, No. 5. pp. 481-483.
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Harman, FS, Nicol, CJ, Marin, HE, Ward, JM, Gonzalez, FJ & Peters, JM 2004, 'Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis', Nature Medicine, vol. 10, no. 5, pp. 481-483. https://doi.org/10.1038/nm1026

Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis. / Harman, Fred S.; Nicol, Christopher J.; Marin, Holly E.; Ward, Jerrold M.; Gonzalez, Frank J.; Peters, Jeffrey M.

In: Nature Medicine, Vol. 10, No. 5, 01.05.2004, p. 481-483.

Research output: Contribution to journalArticle

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