Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Peroxisome proliferators (PPs) are an important group of chemicals that include certain hypolipidemic drugs, plasticizers and pollutants. Many of these agents are known rodent liver tumor promoters and debate exists as to whether humans are at increased cancer risk following exposure to PPs. Research over the last decade has focused on determining the biochemical and molecular mechanisms by which peroxisome proliferators exert their effects, in the hope that this controversy will be settled. PPs regulate gene expression via asteroid hormone receptor, the peroxisome proliferator- activated receptor (PPAR). At least three subtypes of PPAR (α, β and γ) have been cloned from several species, including humans. These receptors have been implicated in tumor promotion, cellular differentiation, and apoptosis. In the present article, the current understanding of how PPARs are involved in tumorigenesis, and what this may mean to human risk assessment, will be discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalToxicological Sciences
Volume47
Issue number1
DOIs
StatePublished - May 18 1999

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Peroxisome Proliferators
Peroxisome Proliferator-Activated Receptors
Carcinogenesis
Minor Planets
Hypolipidemic Agents
Plasticizers
Asteroids
Gene expression
Carcinogens
Liver
Risk assessment
Tumors
Rodentia
Neoplasms
Hormones
Apoptosis
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. / Vanden Heuvel, John Patrick.

In: Toxicological Sciences, Vol. 47, No. 1, 18.05.1999, p. 1-8.

Research output: Contribution to journalReview article

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