Abstract
The 24-hour integrated concentration of aldosterone, plasma renin activity, and 17-hydroxprogesteronewas measured simultaneously in 12 patients with congenital virilizing adrenal hyperplasia due to 21-hydroxylase deficiency. Eight were salt-losers and four nonsalt-lowers. Seven normal children served as control subjects. All patients were receiving glucocorticoid replacement therapy (32 mg/m2/day). All but one of the SL-CVAH patients were also being treated with 9α-fluorocortisol. The mean (±SD) IC-PRA of the control subjects was 1.6±0.7 ng/ml/hour and in the NSL-CVAH patients was similar (1.6±0.7 and 2.2±1.0 ng/ml/hour). The IC-PRA of the SL-CVAH patients (21.1±28.8 ng/ml/hour) was significantly (P<0.001) higher than that of the normal subjects. The IC-ALDO/IC-PRA ratio of the control subjects and NSL-CVAH patients were 12.4±5.1 and 8.8±4.8, respectively. The ratio in SL-CVAH patients was significantly lower (2.0±1.4) than that of the control subjects (P<0.001). The lowered IC-AL DO/IC-PRA ratio in the SL-CVAH patients demonstrates the persistence of the 21-hydroxylase deficiency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 534-537 |
| Number of pages | 4 |
| Journal | The Journal of Pediatrics |
| Volume | 95 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1979 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Persistence of the enzymatic block in adolescent patients with salt-losing congenital adrenal hyperplasia. / Edwin, Chandra; Lanes, Roberto; Migeon, Claude J.; Lee, Peter; Plotnick, Leslie P.; Kowarski, A. Avinoam.
In: The Journal of Pediatrics, Vol. 95, No. 4, 01.01.1979, p. 534-537.Research output: Contribution to journal › Article
TY - JOUR
T1 - Persistence of the enzymatic block in adolescent patients with salt-losing congenital adrenal hyperplasia
AU - Edwin, Chandra
AU - Lanes, Roberto
AU - Migeon, Claude J.
AU - Lee, Peter
AU - Plotnick, Leslie P.
AU - Kowarski, A. Avinoam
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The 24-hour integrated concentration of aldosterone, plasma renin activity, and 17-hydroxprogesteronewas measured simultaneously in 12 patients with congenital virilizing adrenal hyperplasia due to 21-hydroxylase deficiency. Eight were salt-losers and four nonsalt-lowers. Seven normal children served as control subjects. All patients were receiving glucocorticoid replacement therapy (32 mg/m2/day). All but one of the SL-CVAH patients were also being treated with 9α-fluorocortisol. The mean (±SD) IC-PRA of the control subjects was 1.6±0.7 ng/ml/hour and in the NSL-CVAH patients was similar (1.6±0.7 and 2.2±1.0 ng/ml/hour). The IC-PRA of the SL-CVAH patients (21.1±28.8 ng/ml/hour) was significantly (P<0.001) higher than that of the normal subjects. The IC-ALDO/IC-PRA ratio of the control subjects and NSL-CVAH patients were 12.4±5.1 and 8.8±4.8, respectively. The ratio in SL-CVAH patients was significantly lower (2.0±1.4) than that of the control subjects (P<0.001). The lowered IC-AL DO/IC-PRA ratio in the SL-CVAH patients demonstrates the persistence of the 21-hydroxylase deficiency.
AB - The 24-hour integrated concentration of aldosterone, plasma renin activity, and 17-hydroxprogesteronewas measured simultaneously in 12 patients with congenital virilizing adrenal hyperplasia due to 21-hydroxylase deficiency. Eight were salt-losers and four nonsalt-lowers. Seven normal children served as control subjects. All patients were receiving glucocorticoid replacement therapy (32 mg/m2/day). All but one of the SL-CVAH patients were also being treated with 9α-fluorocortisol. The mean (±SD) IC-PRA of the control subjects was 1.6±0.7 ng/ml/hour and in the NSL-CVAH patients was similar (1.6±0.7 and 2.2±1.0 ng/ml/hour). The IC-PRA of the SL-CVAH patients (21.1±28.8 ng/ml/hour) was significantly (P<0.001) higher than that of the normal subjects. The IC-ALDO/IC-PRA ratio of the control subjects and NSL-CVAH patients were 12.4±5.1 and 8.8±4.8, respectively. The ratio in SL-CVAH patients was significantly lower (2.0±1.4) than that of the control subjects (P<0.001). The lowered IC-AL DO/IC-PRA ratio in the SL-CVAH patients demonstrates the persistence of the 21-hydroxylase deficiency.
UR - http://www.scopus.com/inward/record.url?scp=0018292673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018292673&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(79)80757-X
DO - 10.1016/S0022-3476(79)80757-X
M3 - Article
C2 - 314501
AN - SCOPUS:0018292673
VL - 95
SP - 534
EP - 537
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -