Persistent pain associated with long-term intrathecal morphine administration

Winston C.V. Parris, Piotr Janicki, Benjamin Johnson, Janice Livengood, Letha Mathews

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of opioid therapy, and psychologic interventions. Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and morphine-6-glucuronide were analyzed at the beginning of our interventions, and the results indicated that morphine-3-glucuronide levels were significantly higher than morphine-6-glucuronide levels. The possible association between the observed morphine metabolite ratio and the intractable pain in patients resistant to opioids may have potential clinical implications.

Original languageEnglish (US)
Pages (from-to)417-419
Number of pages3
JournalSouthern Medical Journal
Volume89
Issue number4
DOIs
StatePublished - Apr 1 1996

Fingerprint

Morphine
Pain
Opioid Analgesics
Intractable Pain
Nerve Block
Sciatic Nerve
Lower Extremity
Urine
Therapeutics
morphine-3-glucuronide
morphine-6-glucuronide

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Parris, Winston C.V. ; Janicki, Piotr ; Johnson, Benjamin ; Livengood, Janice ; Mathews, Letha. / Persistent pain associated with long-term intrathecal morphine administration. In: Southern Medical Journal. 1996 ; Vol. 89, No. 4. pp. 417-419.
@article{2372de55d6d4422ab0226a12e51d669e,
title = "Persistent pain associated with long-term intrathecal morphine administration",
abstract = "A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of opioid therapy, and psychologic interventions. Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and morphine-6-glucuronide were analyzed at the beginning of our interventions, and the results indicated that morphine-3-glucuronide levels were significantly higher than morphine-6-glucuronide levels. The possible association between the observed morphine metabolite ratio and the intractable pain in patients resistant to opioids may have potential clinical implications.",
author = "Parris, {Winston C.V.} and Piotr Janicki and Benjamin Johnson and Janice Livengood and Letha Mathews",
year = "1996",
month = "4",
day = "1",
doi = "10.1097/00007611-199604000-00014",
language = "English (US)",
volume = "89",
pages = "417--419",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Persistent pain associated with long-term intrathecal morphine administration. / Parris, Winston C.V.; Janicki, Piotr; Johnson, Benjamin; Livengood, Janice; Mathews, Letha.

In: Southern Medical Journal, Vol. 89, No. 4, 01.04.1996, p. 417-419.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Persistent pain associated with long-term intrathecal morphine administration

AU - Parris, Winston C.V.

AU - Janicki, Piotr

AU - Johnson, Benjamin

AU - Livengood, Janice

AU - Mathews, Letha

PY - 1996/4/1

Y1 - 1996/4/1

N2 - A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of opioid therapy, and psychologic interventions. Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and morphine-6-glucuronide were analyzed at the beginning of our interventions, and the results indicated that morphine-3-glucuronide levels were significantly higher than morphine-6-glucuronide levels. The possible association between the observed morphine metabolite ratio and the intractable pain in patients resistant to opioids may have potential clinical implications.

AB - A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of opioid therapy, and psychologic interventions. Plasma and urine ratios of morphine metabolites morphine-3- glucuronide and morphine-6-glucuronide were analyzed at the beginning of our interventions, and the results indicated that morphine-3-glucuronide levels were significantly higher than morphine-6-glucuronide levels. The possible association between the observed morphine metabolite ratio and the intractable pain in patients resistant to opioids may have potential clinical implications.

UR - http://www.scopus.com/inward/record.url?scp=0029930235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029930235&partnerID=8YFLogxK

U2 - 10.1097/00007611-199604000-00014

DO - 10.1097/00007611-199604000-00014

M3 - Article

C2 - 8614885

AN - SCOPUS:0029930235

VL - 89

SP - 417

EP - 419

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 4

ER -