Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow

Tugba Ozdemir, Erin Gaddes, Yong Wang, Cheng Dong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metastasis is a complex process that ultimately results in secondary tumor formation, posing a threat to patient survival. However, the mechanisms by which circulating tumor cells adhere to the endothelium and escape from the vasculature are not fully understood. To bind to the endothelium, tumor cells must resist the shear forces induced by flow, largely through receptor-mediated cell–cell interactions. Tumor cells are able to manipulate the metastatic site microenvironment via thrombin and soluble fibrin (sFn) regulation, impacting both coagulation and cell adhesion processes. Thus, thrombosis may be recognized as a prognostic indicator of highly metastatic tumors. Herein, we describe some correlations between the metastatic potential of tumor cells and coagulation. This perspectives review focuses on the role of sFn in melanoma-endothelial adhesions under shear conditions. Specifically, sFn serves as a divalent ligand for αvβ3, CD11b/CD18 (αmβ2, Mac-1), and intercellular adhesion molecule-1 (ICAM-1) transmembrane receptors. The cross-linking role of sFn is examined in relation to host leukocytes, in particular, the polymorphonuclear neutrophil (PMN)-mediated adhesions of melanoma cells to the endothelium. These results have shed light on the significant interplay between melanoma cells, PMNs, and the endothelium under shear conditions, which is key in the struggle to better diagnose and treat melanoma metastases.

Original languageEnglish (US)
Pages (from-to)86-95
Number of pages10
JournalCellular and Molecular Bioengineering
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Melanoma
Shear flow
Shear Flow
Adhesion
Receptor
Endothelium
Tumors
Tumor
Fibrin
Cell
Cells
Neoplasms
Metastasis
Cell Adhesion
Coagulation
Neoplasm Metastasis
Circulating Neoplastic Cells
Adhesion Molecules
Thrombosis
Neutrophils

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{fb0487dbb79c4baa85604a41d32c3274,
title = "Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow",
abstract = "Metastasis is a complex process that ultimately results in secondary tumor formation, posing a threat to patient survival. However, the mechanisms by which circulating tumor cells adhere to the endothelium and escape from the vasculature are not fully understood. To bind to the endothelium, tumor cells must resist the shear forces induced by flow, largely through receptor-mediated cell–cell interactions. Tumor cells are able to manipulate the metastatic site microenvironment via thrombin and soluble fibrin (sFn) regulation, impacting both coagulation and cell adhesion processes. Thus, thrombosis may be recognized as a prognostic indicator of highly metastatic tumors. Herein, we describe some correlations between the metastatic potential of tumor cells and coagulation. This perspectives review focuses on the role of sFn in melanoma-endothelial adhesions under shear conditions. Specifically, sFn serves as a divalent ligand for αvβ3, CD11b/CD18 (αmβ2, Mac-1), and intercellular adhesion molecule-1 (ICAM-1) transmembrane receptors. The cross-linking role of sFn is examined in relation to host leukocytes, in particular, the polymorphonuclear neutrophil (PMN)-mediated adhesions of melanoma cells to the endothelium. These results have shed light on the significant interplay between melanoma cells, PMNs, and the endothelium under shear conditions, which is key in the struggle to better diagnose and treat melanoma metastases.",
author = "Tugba Ozdemir and Erin Gaddes and Yong Wang and Cheng Dong",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/s12195-014-0369-0",
language = "English (US)",
volume = "8",
pages = "86--95",
journal = "Cellular and Molecular Bioengineering",
issn = "1865-5025",
publisher = "Springer New York",
number = "1",

}

Perspectives : Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow. / Ozdemir, Tugba; Gaddes, Erin; Wang, Yong; Dong, Cheng.

In: Cellular and Molecular Bioengineering, Vol. 8, No. 1, 01.01.2015, p. 86-95.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perspectives

T2 - Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow

AU - Ozdemir, Tugba

AU - Gaddes, Erin

AU - Wang, Yong

AU - Dong, Cheng

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Metastasis is a complex process that ultimately results in secondary tumor formation, posing a threat to patient survival. However, the mechanisms by which circulating tumor cells adhere to the endothelium and escape from the vasculature are not fully understood. To bind to the endothelium, tumor cells must resist the shear forces induced by flow, largely through receptor-mediated cell–cell interactions. Tumor cells are able to manipulate the metastatic site microenvironment via thrombin and soluble fibrin (sFn) regulation, impacting both coagulation and cell adhesion processes. Thus, thrombosis may be recognized as a prognostic indicator of highly metastatic tumors. Herein, we describe some correlations between the metastatic potential of tumor cells and coagulation. This perspectives review focuses on the role of sFn in melanoma-endothelial adhesions under shear conditions. Specifically, sFn serves as a divalent ligand for αvβ3, CD11b/CD18 (αmβ2, Mac-1), and intercellular adhesion molecule-1 (ICAM-1) transmembrane receptors. The cross-linking role of sFn is examined in relation to host leukocytes, in particular, the polymorphonuclear neutrophil (PMN)-mediated adhesions of melanoma cells to the endothelium. These results have shed light on the significant interplay between melanoma cells, PMNs, and the endothelium under shear conditions, which is key in the struggle to better diagnose and treat melanoma metastases.

AB - Metastasis is a complex process that ultimately results in secondary tumor formation, posing a threat to patient survival. However, the mechanisms by which circulating tumor cells adhere to the endothelium and escape from the vasculature are not fully understood. To bind to the endothelium, tumor cells must resist the shear forces induced by flow, largely through receptor-mediated cell–cell interactions. Tumor cells are able to manipulate the metastatic site microenvironment via thrombin and soluble fibrin (sFn) regulation, impacting both coagulation and cell adhesion processes. Thus, thrombosis may be recognized as a prognostic indicator of highly metastatic tumors. Herein, we describe some correlations between the metastatic potential of tumor cells and coagulation. This perspectives review focuses on the role of sFn in melanoma-endothelial adhesions under shear conditions. Specifically, sFn serves as a divalent ligand for αvβ3, CD11b/CD18 (αmβ2, Mac-1), and intercellular adhesion molecule-1 (ICAM-1) transmembrane receptors. The cross-linking role of sFn is examined in relation to host leukocytes, in particular, the polymorphonuclear neutrophil (PMN)-mediated adhesions of melanoma cells to the endothelium. These results have shed light on the significant interplay between melanoma cells, PMNs, and the endothelium under shear conditions, which is key in the struggle to better diagnose and treat melanoma metastases.

UR - http://www.scopus.com/inward/record.url?scp=84925512219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925512219&partnerID=8YFLogxK

U2 - 10.1007/s12195-014-0369-0

DO - 10.1007/s12195-014-0369-0

M3 - Article

AN - SCOPUS:84925512219

VL - 8

SP - 86

EP - 95

JO - Cellular and Molecular Bioengineering

JF - Cellular and Molecular Bioengineering

SN - 1865-5025

IS - 1

ER -