Perspectives on integrated continuous bioprocessing - opportunities and challenges

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Biopharmaceuticals are currently produced almost entirely using batch operations. Integrated continuous processes have the potential to revolutionize bioprocessing, leading to significant reductions in manufacturing costs and facility size while improving product quality through enhanced uniformity in the microenvironment. This paper examines the potential opportunities and challenges in implementing continuous processes for the production of high value biological products. Although regulatory agencies seem highly open to continuous processing, there are significant technical and practical issues that must be addressed to move the industry in this direction, including the development of effective alternatives to traditional downstream processing operations. Continuous processing could provide unique opportunities for the production and delivery of low-cost biopharmaceuticals for solution of major global health challenges in the coming decades.

Original languageEnglish (US)
Article number251
Pages (from-to)8-13
Number of pages6
JournalCurrent Opinion in Chemical Engineering
Volume10
DOIs
StatePublished - Jul 25 2015

Fingerprint

Processing
Costs
Health
Industry

All Science Journal Classification (ASJC) codes

  • Energy(all)

Cite this

@article{ec83bae21acc435692ea072dbc0aed84,
title = "Perspectives on integrated continuous bioprocessing - opportunities and challenges",
abstract = "Biopharmaceuticals are currently produced almost entirely using batch operations. Integrated continuous processes have the potential to revolutionize bioprocessing, leading to significant reductions in manufacturing costs and facility size while improving product quality through enhanced uniformity in the microenvironment. This paper examines the potential opportunities and challenges in implementing continuous processes for the production of high value biological products. Although regulatory agencies seem highly open to continuous processing, there are significant technical and practical issues that must be addressed to move the industry in this direction, including the development of effective alternatives to traditional downstream processing operations. Continuous processing could provide unique opportunities for the production and delivery of low-cost biopharmaceuticals for solution of major global health challenges in the coming decades.",
author = "Andrew Zydney",
year = "2015",
month = "7",
day = "25",
doi = "10.1016/j.coche.2015.07.005",
language = "English (US)",
volume = "10",
pages = "8--13",
journal = "Current Opinion in Chemical Engineering",
issn = "2211-3398",
publisher = "Elsevier BV",

}

Perspectives on integrated continuous bioprocessing - opportunities and challenges. / Zydney, Andrew.

In: Current Opinion in Chemical Engineering, Vol. 10, 251, 25.07.2015, p. 8-13.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Perspectives on integrated continuous bioprocessing - opportunities and challenges

AU - Zydney, Andrew

PY - 2015/7/25

Y1 - 2015/7/25

N2 - Biopharmaceuticals are currently produced almost entirely using batch operations. Integrated continuous processes have the potential to revolutionize bioprocessing, leading to significant reductions in manufacturing costs and facility size while improving product quality through enhanced uniformity in the microenvironment. This paper examines the potential opportunities and challenges in implementing continuous processes for the production of high value biological products. Although regulatory agencies seem highly open to continuous processing, there are significant technical and practical issues that must be addressed to move the industry in this direction, including the development of effective alternatives to traditional downstream processing operations. Continuous processing could provide unique opportunities for the production and delivery of low-cost biopharmaceuticals for solution of major global health challenges in the coming decades.

AB - Biopharmaceuticals are currently produced almost entirely using batch operations. Integrated continuous processes have the potential to revolutionize bioprocessing, leading to significant reductions in manufacturing costs and facility size while improving product quality through enhanced uniformity in the microenvironment. This paper examines the potential opportunities and challenges in implementing continuous processes for the production of high value biological products. Although regulatory agencies seem highly open to continuous processing, there are significant technical and practical issues that must be addressed to move the industry in this direction, including the development of effective alternatives to traditional downstream processing operations. Continuous processing could provide unique opportunities for the production and delivery of low-cost biopharmaceuticals for solution of major global health challenges in the coming decades.

UR - http://www.scopus.com/inward/record.url?scp=84937888574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937888574&partnerID=8YFLogxK

U2 - 10.1016/j.coche.2015.07.005

DO - 10.1016/j.coche.2015.07.005

M3 - Review article

AN - SCOPUS:84937888574

VL - 10

SP - 8

EP - 13

JO - Current Opinion in Chemical Engineering

JF - Current Opinion in Chemical Engineering

SN - 2211-3398

M1 - 251

ER -