Peutz-Jeghers syndrome

Thomas J. McGarrity, Howard E. Kulin, Richard J. Zaino

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations

Abstract

Peutz-Jeghers syndrome (PJS) is an unusual polyposis syndrome that has enjoyed a rich and somewhat confusing history. Mucocutaneous pigmentation and diffuse gastrointestinal hamartomas are the hallmark features of this autosomal dominant inherited condition. Peutz-Jeghers syndrome is now also recognized as a cancer predisposition syndrome. In this review, we highlight the historical aspects of PJS polyposis with special emphasis on its extraintestinal manifestations, particularly genital tract tumors. A PJS management scheme for clinicians is included. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)596-604
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume95
Issue number3
DOIs
StatePublished - Mar 2000

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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