Phagocytosis of biodegradable polymeric particles

H. Ayhan, V. F. Ozyayla, E. B. Denkbas, X. Kaitian, H. Cicek, A. Tuncel, E. Piskin

Research output: Contribution to journalArticle

Abstract

Injectable micron-sized polymeric particles were prepared and used as carriers of radiolabels and drugs for diagnosis and radiotherapy. Monosize polyethylcyanoacrylate (PECA) microspheres were prepared by phase inversion polymerization. Polylactide and polylactide/polyethyleneglycol (PLA/PEG) particles were obtained by solvent evaporation. Albumin and fibronectin were also physically adsorbed on these particles. Phagocytosis of these particles using fresh human blood, and homogeneous mouse peritoneal and lung macrophage suspensions was evaluated. The results were evaluated by phase-contrast microscopy.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering

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    Ayhan, H., Ozyayla, V. F., Denkbas, E. B., Kaitian, X., Cicek, H., Tuncel, A., & Piskin, E. (1994). Phagocytosis of biodegradable polymeric particles. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 22(5).