@article{f550c6cb688f48ea89925ba7239a2ab6,
title = "Pharmacogenomic testing for mental health (Part I): Documenting early adopter perceptions of use for eight scenarios",
abstract = "Aim: We sought to understand how early adopters used pharmacogenomic (PGx) testing for treating depression and attention deficient hyperactivity disorder (ADHD). Patients & methods: We conducted a phone survey with prescribers who had previously ordered an Informed PGx (Progenity, Inc., MI, USA) test. Results: We identified 1037 prescribers in our sampling period. Respondents (n = 64) were predominantly female (61.5%) and in pediatrics (n = 42; 64.6%). PGx testing was used for multiple scenarios (mean 3.3 ± 1.6); the most common was after no response to medication was observed (80%; 51/64). Most respondents state that test results typically reveal an altered metabolizer status. Conclusion: PGx test results ordered by early adopters often reveal altered metabolizers which leads them to change the depression/ADHD medication regimen. Future work should evaluate the clinical utility of PGx testing for depression/ADHD treatment. ",
author = "{Manzor Mitrzyk}, Beatriz and Plegue, {Melissa A.} and Reema Kadri and Danak, {Shivang U.} and Hubbard, {Joseph D.} and Kaip, {Emily A.} and Roberson, {Dana N.} and Ellingrod, {Vicki L.} and Farris, {Karen B.} and Ruffin, {MacK T.} and Klinkman, {Michael S.} and Buis, {Lorraine R.}",
note = "Funding Information: This research was funded by Progenity, Inc.; however, Progenity Inc. had no control or influence over data collection, analysis or the drafting of this manuscript. This study was also funded by MCubed, which is part of the University of Michigan{\textquoteright}s Third Century Initiative, established by the offices of the President and Provost, and housed in the University of Michigan{\textquoteright}s Office of Research (UMOR). LR Buis is obliged to disclose a conflict of interest, as her spouse is an employee and stock holder at Progenity. MT Ruffin is supported by The Hershey Company Professorship and the Dr And Mrs Forney P George Fellowship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 ",
year = "2021",
month = may,
doi = "10.2217/pme-2020-0083",
language = "English (US)",
volume = "18",
pages = "223--232",
journal = "Personalized Medicine",
issn = "1741-0541",
publisher = "Future Medicine Ltd.",
number = "3",
}
