Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

Joel E. Michalek, James L. Pirkle, Larry L. Needham, Donald G. Patterson, Samuel P. Caudill, Ram C. Tripathi, Paolo Mocarelli

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Abstract

A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.

Original languageEnglish (US)
Pages (from-to)44-53
Number of pages10
JournalJournal of Exposure Analysis and Environmental Epidemiology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Toxicology
  • Environmental Science(all)
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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    Michalek, J. E., Pirkle, J. L., Needham, L. L., Patterson, D. G., Caudill, S. P., Tripathi, R. C., & Mocarelli, P. (2002). Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. Journal of Exposure Analysis and Environmental Epidemiology, 12(1), 44-53. https://doi.org/10.1038/sj/jea/7500201