Pharmacokinetics of gentamicin sulfate in bronchial secretions.

J. E. Pennington, Herbert Reynolds

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Dogs were used as a model for the study of the rate of appearance, peak concentrations, and rate of clearance of gentamicin sulfate in bronchial secretions. Gentamicin (dose, 1.7 mg/kg) was given by rapid intravenous infusion, by intramuscular injection, or as two divided intramuscular injections with a 4-hr interval. Intravenous infusion resulted in the highest bronchial concentrations of gentamicin, but the drug was cleared from the respiratory secretions in approximately 3 hr. In contrast, intramuscular injections gave low but more sustained bronchial leves of the drug. The time during which bronchial gentamicin concentrations exceeded a particular minimal inhibitory concentration for a susceptible bacterium such as Pseudomonas was related to the method of drug administration. Thus, to achieve the maximal antibiotic effectiveness, the minimal inhibitory concentraiton of gentamicin for the microorganism should be considered when the dose or frequency of parenteral gentamicin is prescribed.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalThe Journal of infectious diseases
Volume131
Issue number2
DOIs
StatePublished - Jan 1 1975

Fingerprint

Gentamicins
Pharmacokinetics
Intramuscular Injections
Intravenous Infusions
Pharmaceutical Preparations
Pseudomonas
Dogs
Anti-Bacterial Agents
Bacteria

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Pennington, J. E. ; Reynolds, Herbert. / Pharmacokinetics of gentamicin sulfate in bronchial secretions. In: The Journal of infectious diseases. 1975 ; Vol. 131, No. 2. pp. 158-162.
@article{3abcff7f32434faaa90f8add7f54cbbc,
title = "Pharmacokinetics of gentamicin sulfate in bronchial secretions.",
abstract = "Dogs were used as a model for the study of the rate of appearance, peak concentrations, and rate of clearance of gentamicin sulfate in bronchial secretions. Gentamicin (dose, 1.7 mg/kg) was given by rapid intravenous infusion, by intramuscular injection, or as two divided intramuscular injections with a 4-hr interval. Intravenous infusion resulted in the highest bronchial concentrations of gentamicin, but the drug was cleared from the respiratory secretions in approximately 3 hr. In contrast, intramuscular injections gave low but more sustained bronchial leves of the drug. The time during which bronchial gentamicin concentrations exceeded a particular minimal inhibitory concentration for a susceptible bacterium such as Pseudomonas was related to the method of drug administration. Thus, to achieve the maximal antibiotic effectiveness, the minimal inhibitory concentraiton of gentamicin for the microorganism should be considered when the dose or frequency of parenteral gentamicin is prescribed.",
author = "Pennington, {J. E.} and Herbert Reynolds",
year = "1975",
month = "1",
day = "1",
doi = "10.1093/infdis/131.2.158",
language = "English (US)",
volume = "131",
pages = "158--162",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

Pharmacokinetics of gentamicin sulfate in bronchial secretions. / Pennington, J. E.; Reynolds, Herbert.

In: The Journal of infectious diseases, Vol. 131, No. 2, 01.01.1975, p. 158-162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmacokinetics of gentamicin sulfate in bronchial secretions.

AU - Pennington, J. E.

AU - Reynolds, Herbert

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Dogs were used as a model for the study of the rate of appearance, peak concentrations, and rate of clearance of gentamicin sulfate in bronchial secretions. Gentamicin (dose, 1.7 mg/kg) was given by rapid intravenous infusion, by intramuscular injection, or as two divided intramuscular injections with a 4-hr interval. Intravenous infusion resulted in the highest bronchial concentrations of gentamicin, but the drug was cleared from the respiratory secretions in approximately 3 hr. In contrast, intramuscular injections gave low but more sustained bronchial leves of the drug. The time during which bronchial gentamicin concentrations exceeded a particular minimal inhibitory concentration for a susceptible bacterium such as Pseudomonas was related to the method of drug administration. Thus, to achieve the maximal antibiotic effectiveness, the minimal inhibitory concentraiton of gentamicin for the microorganism should be considered when the dose or frequency of parenteral gentamicin is prescribed.

AB - Dogs were used as a model for the study of the rate of appearance, peak concentrations, and rate of clearance of gentamicin sulfate in bronchial secretions. Gentamicin (dose, 1.7 mg/kg) was given by rapid intravenous infusion, by intramuscular injection, or as two divided intramuscular injections with a 4-hr interval. Intravenous infusion resulted in the highest bronchial concentrations of gentamicin, but the drug was cleared from the respiratory secretions in approximately 3 hr. In contrast, intramuscular injections gave low but more sustained bronchial leves of the drug. The time during which bronchial gentamicin concentrations exceeded a particular minimal inhibitory concentration for a susceptible bacterium such as Pseudomonas was related to the method of drug administration. Thus, to achieve the maximal antibiotic effectiveness, the minimal inhibitory concentraiton of gentamicin for the microorganism should be considered when the dose or frequency of parenteral gentamicin is prescribed.

UR - http://www.scopus.com/inward/record.url?scp=0016469067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016469067&partnerID=8YFLogxK

U2 - 10.1093/infdis/131.2.158

DO - 10.1093/infdis/131.2.158

M3 - Article

VL - 131

SP - 158

EP - 162

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -