Pharmacologic manipulation of steroid hormones. Adjunctive therapies in cancer of the breast

3 Scopus citations


Tamoxifen is the endocrine treatment of choice for hormone-responsive early and advanced breast cancer. Newly developed biodegradable luteinizing hormone-releasing hormone super agonists represent a practical and effective treatment for metastatic disease in premenopausal women. Progestins or aromatase inhibitors are useful therapies in patients who relapse from antiestrogens. Currently, there is no indication that improved survival can be achieved by combined endocrine therapy or combined chemo-hormonal therapy.

Original languageEnglish (US)
Pages (from-to)825-844
Number of pages20
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
Publication statusPublished - 1991


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

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