Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report

Jonathan A. Fridell, Ashok Kumar B. Jain, Kusum Patel, Mohamed Virji, K. N. Rao, John J. Fung, Raman Venkataramanan

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalTherapeutic Drug Monitoring
Volume25
Issue number1
DOIs
StatePublished - Feb 1 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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