Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation

Tatsuyuki Kai, Hideo Kimura, Yutaka Shiga, Shin Mineishi, Satoshi Yoshihara, Hiroyasu Ogawa, Etsuko Maruya, Hiroh Saji, Hitoshi Ohto, Yukio Maruyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 32-year-old female patient who had Philadelphia chromosome-positive acute lymphoblastic leukemia underwent cord blood transplantation while in her second remission. However, she had a hematological and central nervous system relapse 3 months later. After reinduction with imatinib mesylate, unmanipulated peripheral blood stem cell transplantation was performed from the patient's haploidentical mother with a reduced-intensity conditioning regimen. Rabbit antithymocyte globulin, tacrolimus, and methylprednisolone were used for prophylaxis of graft-versus-host disease. Engraftment of neutrophils was observed on day 12, and complete donor chimerism was obtained by day 24. The posttransplantation course was uneventful. Although the patient had a relapse 10 months later, this case demonstrated that transplantation from a haploidentical donor is clearly a feasible alternative for patients who desperately need rescue transplantation.

Original languageEnglish (US)
Pages (from-to)453-457
Number of pages5
JournalInternational journal of hematology
Volume80
Issue number5
DOIs
StatePublished - Dec 1 2004

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Philadelphia Chromosome
Stem Cell Transplantation
Fetal Blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transplantation
Mothers
Recurrence
Tissue Donors
Peripheral Blood Stem Cell Transplantation
Chimerism
Antilymphocyte Serum
Methylprednisolone
Tacrolimus
Graft vs Host Disease
Neutrophils
Central Nervous System
Rabbits

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Kai, Tatsuyuki ; Kimura, Hideo ; Shiga, Yutaka ; Mineishi, Shin ; Yoshihara, Satoshi ; Ogawa, Hiroyasu ; Maruya, Etsuko ; Saji, Hiroh ; Ohto, Hitoshi ; Maruyama, Yukio. / Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation. In: International journal of hematology. 2004 ; Vol. 80, No. 5. pp. 453-457.
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Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation. / Kai, Tatsuyuki; Kimura, Hideo; Shiga, Yutaka; Mineishi, Shin; Yoshihara, Satoshi; Ogawa, Hiroyasu; Maruya, Etsuko; Saji, Hiroh; Ohto, Hitoshi; Maruyama, Yukio.

In: International journal of hematology, Vol. 80, No. 5, 01.12.2004, p. 453-457.

Research output: Contribution to journalArticle

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AU - Kai, Tatsuyuki

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AU - Shiga, Yutaka

AU - Mineishi, Shin

AU - Yoshihara, Satoshi

AU - Ogawa, Hiroyasu

AU - Maruya, Etsuko

AU - Saji, Hiroh

AU - Ohto, Hitoshi

AU - Maruyama, Yukio

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