Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation

Tatsuyuki Kai, Hideo Kimura, Yutaka Shiga, Shin Mineishi, Satoshi Yoshihara, Hiroyasu Ogawa, Etsuko Maruya, Hiroh Saji, Hitoshi Ohto, Yukio Maruyama

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Abstract

A 32-year-old female patient who had Philadelphia chromosome-positive acute lymphoblastic leukemia underwent cord blood transplantation while in her second remission. However, she had a hematological and central nervous system relapse 3 months later. After reinduction with imatinib mesylate, unmanipulated peripheral blood stem cell transplantation was performed from the patient's haploidentical mother with a reduced-intensity conditioning regimen. Rabbit antithymocyte globulin, tacrolimus, and methylprednisolone were used for prophylaxis of graft-versus-host disease. Engraftment of neutrophils was observed on day 12, and complete donor chimerism was obtained by day 24. The posttransplantation course was uneventful. Although the patient had a relapse 10 months later, this case demonstrated that transplantation from a haploidentical donor is clearly a feasible alternative for patients who desperately need rescue transplantation.

Original languageEnglish (US)
Pages (from-to)453-457
Number of pages5
JournalInternational journal of hematology
Volume80
Issue number5
DOIs
Publication statusPublished - Dec 1 2004

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All Science Journal Classification (ASJC) codes

  • Hematology

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