Anesthetic residues derived from procaine (4), benzocaine (5), chloroprocaine (6), butyl p-aminobenzoate (7), and 2-amino-4-picoline (8) have been linked to trimeric and high-polymeric phosphazene systems through the arylamino function by nucleophilic replacement of halogen in (NPCl2)3 or (NPCl2)n. Total halogen replacement occurred with the trimers and 99–100% replacement with the high polymers when forcing reaction conditions were employed. Mixed-substituent “copolymers” containing methylamino and procaino or 2-amino-4-picolino residues in a 50:50 ratio were also prepared in order to increase the solubility of the polymers in water. Comparisons are made between the small-molecule cyclotriphosphazene model systems and the high polymers.
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Materials Chemistry