Phosphazene High Polymers with Bioactive Substituent Groups: Prospective Anesthetic Aminophosphazenes

Harry R. Allcock, Paul E. Austin, Thomas X. Neenan

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Anesthetic residues derived from procaine (4), benzocaine (5), chloroprocaine (6), butyl p-aminobenzoate (7), and 2-amino-4-picoline (8) have been linked to trimeric and high-polymeric phosphazene systems through the arylamino function by nucleophilic replacement of halogen in (NPCl2)3 or (NPCl2)n. Total halogen replacement occurred with the trimers and 99–100% replacement with the high polymers when forcing reaction conditions were employed. Mixed-substituent “copolymers” containing methylamino and procaino or 2-amino-4-picolino residues in a 50:50 ratio were also prepared in order to increase the solubility of the polymers in water. Comparisons are made between the small-molecule cyclotriphosphazene model systems and the high polymers.

Original languageEnglish (US)
Pages (from-to)689-693
Number of pages5
JournalMacromolecules
Volume15
Issue number3
DOIs
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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