Phospholipase C-coupled receptors and activation of TRPC channels

M. Trebak; L. Lemonnier; J. T. Smyth; G. Vazquez; J. W. Putney

doi:10.1007/978-3-540-34891-7_35

Phospholipase C-coupled receptors and activation of TRPC channels

M. Trebak, L. Lemonnier, J. T. Smyth, G. Vazquez, J. W. Putney

Research output: Chapter in Book/Report/Conference proceeding › Chapter

81 Scopus citations

Abstract

The canonical transient receptor potential (TRPC) cation channels are mammalian homologs of the photoreceptor channel TRP in Drosophila melanogaster. All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. TRPC channels have been proposed to be activated by a variety of signals including store depletion, membrane lipids, and vesicular insertion into the plasma membrane. Here we discuss recent developments in the mode of activation as well as the pharmacological and electrophysiological properties of this important and ubiquitous family of cation channels.

Original language	English (US)
Title of host publication	Transient Receptor Potential (TRP) Channels
Editors	Veit Flockerzi, Bernd Nilius
Pages	593-614
Number of pages	22
DOIs	https://doi.org/10.1007/978-3-540-34891-7_35
State	Published - 2007

Publication series

Name	Handbook of Experimental Pharmacology
Volume	179
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

All Science Journal Classification (ASJC) codes

Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-3-540-34891-7_35

Cite this

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abstract = "The canonical transient receptor potential (TRPC) cation channels are mammalian homologs of the photoreceptor channel TRP in Drosophila melanogaster. All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. TRPC channels have been proposed to be activated by a variety of signals including store depletion, membrane lipids, and vesicular insertion into the plasma membrane. Here we discuss recent developments in the mode of activation as well as the pharmacological and electrophysiological properties of this important and ubiquitous family of cation channels.",

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Phospholipase C-coupled receptors and activation of TRPC channels

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