Phospholipase C-coupled receptors and activation of TRPC channels

M. Trebak, L. Lemonnier, J. T. Smyth, G. Vazquez, J. W. Putney

Research output: Chapter in Book/Report/Conference proceedingChapter

72 Scopus citations

Abstract

The canonical transient receptor potential (TRPC) cation channels are mammalian homologs of the photoreceptor channel TRP in Drosophila melanogaster. All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. TRPC channels have been proposed to be activated by a variety of signals including store depletion, membrane lipids, and vesicular insertion into the plasma membrane. Here we discuss recent developments in the mode of activation as well as the pharmacological and electrophysiological properties of this important and ubiquitous family of cation channels.

Original languageEnglish (US)
Title of host publicationTransient Receptor Potential (TRP) Channels
EditorsVeit Flockerzi, Bernd Nilius
Pages593-614
Number of pages22
DOIs
StatePublished - 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume179
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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