Photoredox-Mediated Minisci Alkylation of N-Heteroarenes using Carboxylic Acids and Hypervalent Iodine

Junhua Wang, Guo Xing Li, Gang He, Gong Chen

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A new protocol of photoredox-mediated Minisci alkylation of N-heteroarenes with aliphatic carboxylic acids has been developed. Using Ru(bpy)3Cl2 as photocatalyst and acetoxybenziodoxole (BI–OAc) as oxidant, a variety of primary, secondary and tertiary alkyl groups can be efficiently incorporated into various electron-deficient N-heteroarenes. This protocol demonstrated excellent substrate scope and good functional group tolerance and can be applied to late-stage functionalization of complex molecules.

Original languageEnglish (US)
Pages (from-to)1307-1310
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume7
Issue number7
DOIs
StatePublished - Jul 2018

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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