Phylogenetic analysis of the mammalian Hoxc8 non-coding region

Chang Bae Kim, Cooduvalli S. Shashikant, Kenta Sumiyama, Wayne C H Wang, Chris T. Amemiya, Frank H. Ruddle

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalJournal of Structural and Functional Genomics
Volume3
Issue number1-4
DOIs
StatePublished - Apr 30 2003

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Intergenic DNA
Homeobox Genes
Felidae
Polymorphism
Genes
Mammals
Phylogeny
Genetic Markers
Satellites

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Genetics

Cite this

Kim, Chang Bae ; Shashikant, Cooduvalli S. ; Sumiyama, Kenta ; Wang, Wayne C H ; Amemiya, Chris T. ; Ruddle, Frank H. / Phylogenetic analysis of the mammalian Hoxc8 non-coding region. In: Journal of Structural and Functional Genomics. 2003 ; Vol. 3, No. 1-4. pp. 195-199.
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Phylogenetic analysis of the mammalian Hoxc8 non-coding region. / Kim, Chang Bae; Shashikant, Cooduvalli S.; Sumiyama, Kenta; Wang, Wayne C H; Amemiya, Chris T.; Ruddle, Frank H.

In: Journal of Structural and Functional Genomics, Vol. 3, No. 1-4, 30.04.2003, p. 195-199.

Research output: Contribution to journalArticle

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