Phylogenetic analysis of the mammalian Hoxc8 non-coding region

Chang Bae Kim, Cooduvalli S. Shashikant, Kenta Sumiyama, Wayne C.H. Wang, Chris T. Amemiya, Frank H. Ruddle

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalJournal of Structural and Functional Genomics
Volume3
Issue number1-4
DOIs
StatePublished - Apr 30 2003

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Genetics

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