Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC

Andrew Rundle, John Richie, Karen Steindorf, Marco Peluso, Kim Overvad, Ole Raaschou-Nielsen, Francoise Clavel-Chapelon, Jacob P. Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Rosario Tumino, Salvatore Panico, Hendrik B. Bueno-De-Mesquita, Petra H. Peeters, Eiliv Lund, Carlos A. Gonzalez, Carmen Martinez, Miren DorronsoroAurelio Barricarte, M. Jose Tormo, José R. Quiros, Antonio Agudo, Goran Berglund, Bengt Jarvholm, Sheila Bingham, Timothy J. Key, Emmanuelle Gormally, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli, Paolo Vineis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

Original languageEnglish (US)
Pages (from-to)20-30
Number of pages11
JournalBiomarkers
Volume15
Issue number1
DOIs
StatePublished - Feb 1 2010

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Epidemiologic Studies
Lung Neoplasms
Odds Ratio
Biomarkers
Confidence Intervals
Blood
Cells
DNA Adducts
Nutrition
Labeling
Glutathione
Hemoglobins
Association reactions
Leukocytes
Erythrocytes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Rundle, A., Richie, J., Steindorf, K., Peluso, M., Overvad, K., Raaschou-Nielsen, O., ... Vineis, P. (2010). Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC. Biomarkers, 15(1), 20-30. https://doi.org/10.3109/13547500903186452
Rundle, Andrew ; Richie, John ; Steindorf, Karen ; Peluso, Marco ; Overvad, Kim ; Raaschou-Nielsen, Ole ; Clavel-Chapelon, Francoise ; Linseisen, Jacob P. ; Boeing, Heiner ; Trichopoulou, Antonia ; Palli, Domenico ; Krogh, Vittorio ; Tumino, Rosario ; Panico, Salvatore ; Bueno-De-Mesquita, Hendrik B. ; Peeters, Petra H. ; Lund, Eiliv ; Gonzalez, Carlos A. ; Martinez, Carmen ; Dorronsoro, Miren ; Barricarte, Aurelio ; Tormo, M. Jose ; Quiros, José R. ; Agudo, Antonio ; Berglund, Goran ; Jarvholm, Bengt ; Bingham, Sheila ; Key, Timothy J. ; Gormally, Emmanuelle ; Saracci, Rodolfo ; Kaaks, Rudolf ; Riboli, Elio ; Vineis, Paolo. / Physical activity and lung cancer among non-smokers : A pilot molecular epidemiological study within EPIC. In: Biomarkers. 2010 ; Vol. 15, No. 1. pp. 20-30.
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Rundle, A, Richie, J, Steindorf, K, Peluso, M, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, JP, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, HB, Peeters, PH, Lund, E, Gonzalez, CA, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Agudo, A, Berglund, G, Jarvholm, B, Bingham, S, Key, TJ, Gormally, E, Saracci, R, Kaaks, R, Riboli, E & Vineis, P 2010, 'Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC', Biomarkers, vol. 15, no. 1, pp. 20-30. https://doi.org/10.3109/13547500903186452

Physical activity and lung cancer among non-smokers : A pilot molecular epidemiological study within EPIC. / Rundle, Andrew; Richie, John; Steindorf, Karen; Peluso, Marco; Overvad, Kim; Raaschou-Nielsen, Ole; Clavel-Chapelon, Francoise; Linseisen, Jacob P.; Boeing, Heiner; Trichopoulou, Antonia; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Panico, Salvatore; Bueno-De-Mesquita, Hendrik B.; Peeters, Petra H.; Lund, Eiliv; Gonzalez, Carlos A.; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Tormo, M. Jose; Quiros, José R.; Agudo, Antonio; Berglund, Goran; Jarvholm, Bengt; Bingham, Sheila; Key, Timothy J.; Gormally, Emmanuelle; Saracci, Rodolfo; Kaaks, Rudolf; Riboli, Elio; Vineis, Paolo.

In: Biomarkers, Vol. 15, No. 1, 01.02.2010, p. 20-30.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physical activity and lung cancer among non-smokers

T2 - A pilot molecular epidemiological study within EPIC

AU - Rundle, Andrew

AU - Richie, John

AU - Steindorf, Karen

AU - Peluso, Marco

AU - Overvad, Kim

AU - Raaschou-Nielsen, Ole

AU - Clavel-Chapelon, Francoise

AU - Linseisen, Jacob P.

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Bueno-De-Mesquita, Hendrik B.

AU - Peeters, Petra H.

AU - Lund, Eiliv

AU - Gonzalez, Carlos A.

AU - Martinez, Carmen

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Tormo, M. Jose

AU - Quiros, José R.

AU - Agudo, Antonio

AU - Berglund, Goran

AU - Jarvholm, Bengt

AU - Bingham, Sheila

AU - Key, Timothy J.

AU - Gormally, Emmanuelle

AU - Saracci, Rodolfo

AU - Kaaks, Rudolf

AU - Riboli, Elio

AU - Vineis, Paolo

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

AB - The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

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