Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors

Justin C. Brown, Lilie L. Lin, Saya Segal, Christina S. Chu, Ashley E. Haggerty, Emily M. Ko, Kathryn H. Schmitz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: We sought to quantify the proportion of uterine cancer survivors who self-report poor physical function. We then sought to quantify the association of poor physical function with physical activity (PA), walking, and lower limb lymphedema (LLL), among women with a history of uterine cancer.

Methods: Physical function was quantified using the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) questionnaire. PA, walking, and LLL were measured using self-report questionnaire. PA was calculated using metabolic equivalent hours per week (MET-h week−1), and walking was calculated using blocks per day (blocks day−1). Logistic regression estimated odds ratios (OR) and 95 % confidence intervals (95 % CI).

Results: Among the 213 uterine cancer survivors in our survey (43 % response rate), 35 % self-reported poor physical function. Compared to participants who reported <3.0 MET-h week−1 of PA, participants who reported ≥18.0 MET-h week−1 of PA were less likely to have poor physical function (OR 0.03, 95 % CI 0.01–0.10; Ptrend < 0.0001). Compared to participants who reported <4.0 blocks day−1 of walking, participants who reported ≥12.0 blocks day−1 of walking were less likely to have poor physical function (OR 0.07, 95 % CI 0.03–0.19; Ptrend < 0.0001). Compared to participants who did not have LLL, participants with LLL were more likely to have poor physical function (OR 5.25, 95 % CI 2.41–11.41; P < 0.0001).

Conclusion: Higher levels of PA and walking associate with a lower likelihood of reporting poor physical function. The presence of LLL associates with a higher likelihood of reporting poor physical function. These findings are hypothesis-generating and should be evaluated in future prospective studies.

Original languageEnglish (US)
Pages (from-to)3017-3025
Number of pages9
JournalSupportive Care in Cancer
Volume22
Issue number11
DOIs
StatePublished - Oct 3 2014

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Uterine Neoplasms
Lymphedema
Walking
Survivors
Lower Extremity
Exercise
Odds Ratio
Confidence Intervals
Self Report
Metabolic Equivalent
Health Surveys
Logistic Models
Outcome Assessment (Health Care)
Prospective Studies
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Brown, Justin C. ; Lin, Lilie L. ; Segal, Saya ; Chu, Christina S. ; Haggerty, Ashley E. ; Ko, Emily M. ; Schmitz, Kathryn H. / Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors. In: Supportive Care in Cancer. 2014 ; Vol. 22, No. 11. pp. 3017-3025.
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title = "Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors",
abstract = "Purpose: We sought to quantify the proportion of uterine cancer survivors who self-report poor physical function. We then sought to quantify the association of poor physical function with physical activity (PA), walking, and lower limb lymphedema (LLL), among women with a history of uterine cancer.Methods: Physical function was quantified using the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) questionnaire. PA, walking, and LLL were measured using self-report questionnaire. PA was calculated using metabolic equivalent hours per week (MET-h week−1), and walking was calculated using blocks per day (blocks day−1). Logistic regression estimated odds ratios (OR) and 95 {\%} confidence intervals (95 {\%} CI).Results: Among the 213 uterine cancer survivors in our survey (43 {\%} response rate), 35 {\%} self-reported poor physical function. Compared to participants who reported <3.0 MET-h week−1 of PA, participants who reported ≥18.0 MET-h week−1 of PA were less likely to have poor physical function (OR 0.03, 95 {\%} CI 0.01–0.10; Ptrend < 0.0001). Compared to participants who reported <4.0 blocks day−1 of walking, participants who reported ≥12.0 blocks day−1 of walking were less likely to have poor physical function (OR 0.07, 95 {\%} CI 0.03–0.19; Ptrend < 0.0001). Compared to participants who did not have LLL, participants with LLL were more likely to have poor physical function (OR 5.25, 95 {\%} CI 2.41–11.41; P < 0.0001).Conclusion: Higher levels of PA and walking associate with a lower likelihood of reporting poor physical function. The presence of LLL associates with a higher likelihood of reporting poor physical function. These findings are hypothesis-generating and should be evaluated in future prospective studies.",
author = "Brown, {Justin C.} and Lin, {Lilie L.} and Saya Segal and Chu, {Christina S.} and Haggerty, {Ashley E.} and Ko, {Emily M.} and Schmitz, {Kathryn H.}",
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Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors. / Brown, Justin C.; Lin, Lilie L.; Segal, Saya; Chu, Christina S.; Haggerty, Ashley E.; Ko, Emily M.; Schmitz, Kathryn H.

In: Supportive Care in Cancer, Vol. 22, No. 11, 03.10.2014, p. 3017-3025.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors

AU - Brown, Justin C.

AU - Lin, Lilie L.

AU - Segal, Saya

AU - Chu, Christina S.

AU - Haggerty, Ashley E.

AU - Ko, Emily M.

AU - Schmitz, Kathryn H.

PY - 2014/10/3

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N2 - Purpose: We sought to quantify the proportion of uterine cancer survivors who self-report poor physical function. We then sought to quantify the association of poor physical function with physical activity (PA), walking, and lower limb lymphedema (LLL), among women with a history of uterine cancer.Methods: Physical function was quantified using the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) questionnaire. PA, walking, and LLL were measured using self-report questionnaire. PA was calculated using metabolic equivalent hours per week (MET-h week−1), and walking was calculated using blocks per day (blocks day−1). Logistic regression estimated odds ratios (OR) and 95 % confidence intervals (95 % CI).Results: Among the 213 uterine cancer survivors in our survey (43 % response rate), 35 % self-reported poor physical function. Compared to participants who reported <3.0 MET-h week−1 of PA, participants who reported ≥18.0 MET-h week−1 of PA were less likely to have poor physical function (OR 0.03, 95 % CI 0.01–0.10; Ptrend < 0.0001). Compared to participants who reported <4.0 blocks day−1 of walking, participants who reported ≥12.0 blocks day−1 of walking were less likely to have poor physical function (OR 0.07, 95 % CI 0.03–0.19; Ptrend < 0.0001). Compared to participants who did not have LLL, participants with LLL were more likely to have poor physical function (OR 5.25, 95 % CI 2.41–11.41; P < 0.0001).Conclusion: Higher levels of PA and walking associate with a lower likelihood of reporting poor physical function. The presence of LLL associates with a higher likelihood of reporting poor physical function. These findings are hypothesis-generating and should be evaluated in future prospective studies.

AB - Purpose: We sought to quantify the proportion of uterine cancer survivors who self-report poor physical function. We then sought to quantify the association of poor physical function with physical activity (PA), walking, and lower limb lymphedema (LLL), among women with a history of uterine cancer.Methods: Physical function was quantified using the Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) questionnaire. PA, walking, and LLL were measured using self-report questionnaire. PA was calculated using metabolic equivalent hours per week (MET-h week−1), and walking was calculated using blocks per day (blocks day−1). Logistic regression estimated odds ratios (OR) and 95 % confidence intervals (95 % CI).Results: Among the 213 uterine cancer survivors in our survey (43 % response rate), 35 % self-reported poor physical function. Compared to participants who reported <3.0 MET-h week−1 of PA, participants who reported ≥18.0 MET-h week−1 of PA were less likely to have poor physical function (OR 0.03, 95 % CI 0.01–0.10; Ptrend < 0.0001). Compared to participants who reported <4.0 blocks day−1 of walking, participants who reported ≥12.0 blocks day−1 of walking were less likely to have poor physical function (OR 0.07, 95 % CI 0.03–0.19; Ptrend < 0.0001). Compared to participants who did not have LLL, participants with LLL were more likely to have poor physical function (OR 5.25, 95 % CI 2.41–11.41; P < 0.0001).Conclusion: Higher levels of PA and walking associate with a lower likelihood of reporting poor physical function. The presence of LLL associates with a higher likelihood of reporting poor physical function. These findings are hypothesis-generating and should be evaluated in future prospective studies.

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