Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome

Ronald G. Lafrenière, Carolyn J. Brown, Vicki E. Powers, Laura Carrel, Kay E. Davies, David F. Barker, Huntington F. Willard

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Using a panel of human/rodent somatic cell hybrids and human lymphoblast lines segregating 18 different human X-chromosome rearrangements and deletions, we have assigned 60 DNA markers to the physical map of the X chromosome from Xp21.1 to Xq21.3. Data from Southern blot hybridization and polymerase chain reaction (PCR) amplification assign these markers to 15 primary map intervals. This provides a basis for further long-range cloning and mapping of the pericentromeric region of the X chromosome.

Original languageEnglish (US)
Pages (from-to)352-363
Number of pages12
JournalGenomics
Volume11
Issue number2
DOIs
StatePublished - Oct 1991

All Science Journal Classification (ASJC) codes

  • Genetics

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    Lafrenière, R. G., Brown, C. J., Powers, V. E., Carrel, L., Davies, K. E., Barker, D. F., & Willard, H. F. (1991). Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome. Genomics, 11(2), 352-363. https://doi.org/10.1016/0888-7543(91)90143-3