Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome

Ronald G. Lafrenière, Carolyn J. Brown, Vicki E. Powers, Laura Carrel, Kay E. Davies, David F. Barker, Huntington F. Willard

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Using a panel of human/rodent somatic cell hybrids and human lymphoblast lines segregating 18 different human X-chromosome rearrangements and deletions, we have assigned 60 DNA markers to the physical map of the X chromosome from Xp21.1 to Xq21.3. Data from Southern blot hybridization and polymerase chain reaction (PCR) amplification assign these markers to 15 primary map intervals. This provides a basis for further long-range cloning and mapping of the pericentromeric region of the X chromosome.

Original languageEnglish (US)
Pages (from-to)352-363
Number of pages12
JournalGenomics
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1991

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Chromosomes, Human, X
X Chromosome
Genetic Markers
Chromosome Deletion
Hybrid Cells
Southern Blotting
Organism Cloning
Rodentia
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Lafrenière, R. G., Brown, C. J., Powers, V. E., Carrel, L., Davies, K. E., Barker, D. F., & Willard, H. F. (1991). Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome. Genomics, 11(2), 352-363. https://doi.org/10.1016/0888-7543(91)90143-3
Lafrenière, Ronald G. ; Brown, Carolyn J. ; Powers, Vicki E. ; Carrel, Laura ; Davies, Kay E. ; Barker, David F. ; Willard, Huntington F. / Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome. In: Genomics. 1991 ; Vol. 11, No. 2. pp. 352-363.
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Lafrenière, RG, Brown, CJ, Powers, VE, Carrel, L, Davies, KE, Barker, DF & Willard, HF 1991, 'Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome', Genomics, vol. 11, no. 2, pp. 352-363. https://doi.org/10.1016/0888-7543(91)90143-3

Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosome. / Lafrenière, Ronald G.; Brown, Carolyn J.; Powers, Vicki E.; Carrel, Laura; Davies, Kay E.; Barker, David F.; Willard, Huntington F.

In: Genomics, Vol. 11, No. 2, 01.01.1991, p. 352-363.

Research output: Contribution to journalArticle

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