Physiologic Effects of Xenon in Xenon-CT Cerebral Blood Flow Studies on Comatose Patients

J. A. Kosty, W. A. Kofke, E. Maloney-Wilensky, S. G. Frangos, J. M. Levine, P. D. LeRoux, E. L. Zager

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Despite more than 30 years of clinical use, questions remain about the safety of xenon gas in Xenon-CT cerebral blood flow (XeCTCBF) studies. In particular, xenon's effect on brain oxygen (PbtO 2) in comatose patients is not well defined. Our objective was to assess the effect of a 4.5-min inhalation of 28% stable xenon on several physiologic variables, including intracranial pressure (ICP), cerebral perfusion pressure (CPP), and PbtO 2 in comatose patients (Glasgow Coma Scale [GCS] ≤ 8). Thirty-seven comatose patients who underwent 73 XeCTCBF studies were identified retrospectively from a prospective observational database. Changes in MAP, HR, SaO 2, EtCO 2, ICP, CPP, and PbtO 2 measured at the start of xenon administration and every minute for 5 min thereafter were assessed. The maximum change in each variable also was determined for each scan to tabulate clinically relevant changes. Statistically, but not clinically significant changes in MAP, HR, and EtCO 2 were seen. Xenon had no effect on ICP, and a small, but clinically insignificant decrease in CPP and PbtO 2, was observed. There was a varied response to xenon in most measured variables. Clinically significant changes in each were infrequent, and readily reversed with the cessation of the gas. We conclude that xenon does not appear to have a clinically significant effect on ICP, CPP, and PbtO 2 and so appears safe to evaluate cerebral blood flow in comatose patients.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalTranslational Stroke Research
Volume3
Issue number3
DOIs
StatePublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this