Physiological and pathophysiological regulation of cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue Hwa Chen, Jaspreet S. Sidhu, Curtis J. Omiecinski

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Abstract

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

Original languageEnglish (US)
Pages (from-to)1232-1240
Number of pages9
JournalDrug Metabolism and Disposition
Volume26
Issue number12
StatePublished - Dec 1 1998

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Morgan, E. T., Sewer, M. B., Iber, H., Gonzalez, F. J., Lee, Y. H., Tukey, R. H., Okino, S., Vu, T., Chen, Y. H., Sidhu, J. S., & Omiecinski, C. J. (1998). Physiological and pathophysiological regulation of cytochrome P450. Drug Metabolism and Disposition, 26(12), 1232-1240.