Abstract
The relationship between body fluid deficits and drinking has been investigated in a nonhuman primate. Intravenous sodium chloride infusions (0.93-3.25 M) given to rhesus monkeys caused drinking correlated with increases in plasma osmolality and sodium concentrations. Sucrose infusions (0.3 M in 0.15 M NaCl) also caused drinking while equiosmolal infusions did not. It was found that the drinking threshold corresponded to a 2.3% increase in plasma osmolality. Water deprivation for 24 h caused significant cellular dehydration, as indicated by a 5.8% elevation in plasma osmolity that exceeded the threshold for thirst, and a significant hypovolemia as indicated by a 5.8% elevation in plasma osmolality that exceeded the threshold for thirst, and a significant hypovolemia as indicated by elevated plasma protein and hematocrit values. Intravenous water preloads decreased plasma osmolality and produced a dose-related decrease in subsequent drinking. Infusions that restored plasma osmolality to predeprivation values, reduced intake by 85% Intravenous isotonic saline preloads which abolished the hypovolemia did not have a consistent effect and reduced mean water intakes by only 3.2%. Thus in the rhesus monkey, cellular dehydration is an effective stimulus for thirst, and it is the primary determinant of drinking after water deprivation, used as an example of a natural thirst stimulus. In contrast to findings in nonprimates the extracellular deficit contributes very little to drinking after water deprivation.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 11 |
| Issue number | 3 |
| State | Published - Jan 1 1982 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Physiology
- Physiology (medical)
Cite this
}
Physiological mechanisms for thirst in the nonhuman primate. / Wood, R. J.; Rolls, E. T.; Rolls, Barbara Jean.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 11, No. 3, 01.01.1982.Research output: Contribution to journal › Article
TY - JOUR
T1 - Physiological mechanisms for thirst in the nonhuman primate
AU - Wood, R. J.
AU - Rolls, E. T.
AU - Rolls, Barbara Jean
PY - 1982/1/1
Y1 - 1982/1/1
N2 - The relationship between body fluid deficits and drinking has been investigated in a nonhuman primate. Intravenous sodium chloride infusions (0.93-3.25 M) given to rhesus monkeys caused drinking correlated with increases in plasma osmolality and sodium concentrations. Sucrose infusions (0.3 M in 0.15 M NaCl) also caused drinking while equiosmolal infusions did not. It was found that the drinking threshold corresponded to a 2.3% increase in plasma osmolality. Water deprivation for 24 h caused significant cellular dehydration, as indicated by a 5.8% elevation in plasma osmolity that exceeded the threshold for thirst, and a significant hypovolemia as indicated by a 5.8% elevation in plasma osmolality that exceeded the threshold for thirst, and a significant hypovolemia as indicated by elevated plasma protein and hematocrit values. Intravenous water preloads decreased plasma osmolality and produced a dose-related decrease in subsequent drinking. Infusions that restored plasma osmolality to predeprivation values, reduced intake by 85% Intravenous isotonic saline preloads which abolished the hypovolemia did not have a consistent effect and reduced mean water intakes by only 3.2%. Thus in the rhesus monkey, cellular dehydration is an effective stimulus for thirst, and it is the primary determinant of drinking after water deprivation, used as an example of a natural thirst stimulus. In contrast to findings in nonprimates the extracellular deficit contributes very little to drinking after water deprivation.
AB - The relationship between body fluid deficits and drinking has been investigated in a nonhuman primate. Intravenous sodium chloride infusions (0.93-3.25 M) given to rhesus monkeys caused drinking correlated with increases in plasma osmolality and sodium concentrations. Sucrose infusions (0.3 M in 0.15 M NaCl) also caused drinking while equiosmolal infusions did not. It was found that the drinking threshold corresponded to a 2.3% increase in plasma osmolality. Water deprivation for 24 h caused significant cellular dehydration, as indicated by a 5.8% elevation in plasma osmolity that exceeded the threshold for thirst, and a significant hypovolemia as indicated by a 5.8% elevation in plasma osmolality that exceeded the threshold for thirst, and a significant hypovolemia as indicated by elevated plasma protein and hematocrit values. Intravenous water preloads decreased plasma osmolality and produced a dose-related decrease in subsequent drinking. Infusions that restored plasma osmolality to predeprivation values, reduced intake by 85% Intravenous isotonic saline preloads which abolished the hypovolemia did not have a consistent effect and reduced mean water intakes by only 3.2%. Thus in the rhesus monkey, cellular dehydration is an effective stimulus for thirst, and it is the primary determinant of drinking after water deprivation, used as an example of a natural thirst stimulus. In contrast to findings in nonprimates the extracellular deficit contributes very little to drinking after water deprivation.
UR - http://www.scopus.com/inward/record.url?scp=0020129999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020129999&partnerID=8YFLogxK
M3 - Article
VL - 11
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3
ER -