Physiology of the upper segment, body, and lower segment of the esophagus

Larry Miller, Pere Clavé, Ricard Farré, Begoña Lecea, Michael R. Ruggieri, Ann Ouyang, Julie Regan, Barry P. Mcmahon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The following discussion on the physiology of the esophagus includes commentaries on the function of the muscularis mucosa and submucosa as a mechanical antireflux barrier in the esophagus; the different mechanisms of neurological control in the esophageal striated and smooth muscle; new insights from animal models into the neurotransmitters mediating lower esophageal sphincter (LES) relaxation, peristalsis in the esophageal body (EB), and motility of esophageal smooth muscle; differentiation between in vitro properties of the lower esophageal circular muscle, clasp muscle, and sling fibers; alterations in the relationship between pharyngeal contraction and relaxation of the upper esophageal sphincter (UES) in patients with dysphagia; the mechanical relationships between anterior hyoid movement, the extent of upper esophageal opening, and aspiration; the application of fluoroscopy and manometry with biomechanics to define the stages of UES opening; and nonpharmacological approaches to alter the gastroesophageal junction (GEJ).

Original languageEnglish (US)
Pages (from-to)261-277
Number of pages17
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
StatePublished - Jan 1 2013

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Upper Esophageal Sphincter
Physiology
Esophagus
Smooth Muscle
Muscle
Peristalsis
Esophagogastric Junction
Muscles
Lower Esophageal Sphincter
Striated Muscle
Fluoroscopy
Manometry
Deglutition Disorders
Biomechanical Phenomena
Neurotransmitter Agents
Mucous Membrane
Animal Models
Slings
Biomechanics
Animals

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Miller, L., Clavé, P., Farré, R., Lecea, B., Ruggieri, M. R., Ouyang, A., ... Mcmahon, B. P. (2013). Physiology of the upper segment, body, and lower segment of the esophagus. Annals of the New York Academy of Sciences, 1300(1), 261-277. https://doi.org/10.1111/nyas.12250
Miller, Larry ; Clavé, Pere ; Farré, Ricard ; Lecea, Begoña ; Ruggieri, Michael R. ; Ouyang, Ann ; Regan, Julie ; Mcmahon, Barry P. / Physiology of the upper segment, body, and lower segment of the esophagus. In: Annals of the New York Academy of Sciences. 2013 ; Vol. 1300, No. 1. pp. 261-277.
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Miller, L, Clavé, P, Farré, R, Lecea, B, Ruggieri, MR, Ouyang, A, Regan, J & Mcmahon, BP 2013, 'Physiology of the upper segment, body, and lower segment of the esophagus', Annals of the New York Academy of Sciences, vol. 1300, no. 1, pp. 261-277. https://doi.org/10.1111/nyas.12250

Physiology of the upper segment, body, and lower segment of the esophagus. / Miller, Larry; Clavé, Pere; Farré, Ricard; Lecea, Begoña; Ruggieri, Michael R.; Ouyang, Ann; Regan, Julie; Mcmahon, Barry P.

In: Annals of the New York Academy of Sciences, Vol. 1300, No. 1, 01.01.2013, p. 261-277.

Research output: Contribution to journalArticle

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