Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment

Nahoko Ogata, Joyce Tombran-Tink, Maki Nishikawa, Tetsuya Nishimura, Yumiko Mitsuma, Taiji Sakamoto, Miyo Matsumura

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To report the levels of pigment epithelium-derived factor in the vitreous of patients with diabetic retinopathy, rhegmatogenous retinal detachment, and idiopathic macular hole. METHODS: Using enzyme-linked immunosorbent assay, we measured the levels of pigment epithelium-derived factor in the vitreous of 34 eyes of 33 patients who underwent vitrectomy for the treatment of diabetic retinopathy (17 eyes of 16 patients), rhegmatogenous retinal detachment (10 eyes), and idiopathic macular hole (seven eyes). RESULTS: The vitreal concentration of pigment epithelium-derived factor was 1.15 ± 0.23 μg/ml (mean ± standard error) in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in rhegmatogenous retinal detachment, and 1.71 ± 0.39 μg/ml in idiopathic macular hole. The pigment epithelium-derived factor level in rhegmatogenous retinal detachment was significantly higher than that in diabetic retinopathy (P = .0008) and idiopathic macular hole (P = .034). For eyes with diabetic retinopathy, the pigment epithelium-derived factor level was 0.88 ± 0.21 μg/ml in proliferative diabetic retinopathy and 2.43 ± 0.37 μg/ml in nonproliferative diabetic retinopathy (P = .0083). Additionally, the pigment epithelium-derived factor level in active diabetic retinopathy (0.70 ± 0.22 μg/ml) was significantly lower than the level in inactive diabetic retinopathy (1.79 ± 0.35 μg/ml; P = .018). CONCLUSIONS: These results suggest that pigment epithelium-derived factor inhibits angiogenesis and that lower levels of pigment epithelium-derived factor may be related to the angiogenesis in diabetic retinopathy and result in active proliferative diabetic retinopathy. The results also suggest that higher levels of pigment epithelium-derived factor in the eyes with rhegmatogenous retinal detachment may act as a neuroprotective agent for the detached retina.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume132
Issue number3
DOIs
StatePublished - Aug 31 2001

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Retinal Detachment
Diabetic Retinopathy
Retinal Perforations
pigment epithelium-derived factor
Vitrectomy
Neuroprotective Agents
Retina
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Ogata, Nahoko ; Tombran-Tink, Joyce ; Nishikawa, Maki ; Nishimura, Tetsuya ; Mitsuma, Yumiko ; Sakamoto, Taiji ; Matsumura, Miyo. / Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. In: American Journal of Ophthalmology. 2001 ; Vol. 132, No. 3. pp. 378-382.
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abstract = "PURPOSE: To report the levels of pigment epithelium-derived factor in the vitreous of patients with diabetic retinopathy, rhegmatogenous retinal detachment, and idiopathic macular hole. METHODS: Using enzyme-linked immunosorbent assay, we measured the levels of pigment epithelium-derived factor in the vitreous of 34 eyes of 33 patients who underwent vitrectomy for the treatment of diabetic retinopathy (17 eyes of 16 patients), rhegmatogenous retinal detachment (10 eyes), and idiopathic macular hole (seven eyes). RESULTS: The vitreal concentration of pigment epithelium-derived factor was 1.15 ± 0.23 μg/ml (mean ± standard error) in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in rhegmatogenous retinal detachment, and 1.71 ± 0.39 μg/ml in idiopathic macular hole. The pigment epithelium-derived factor level in rhegmatogenous retinal detachment was significantly higher than that in diabetic retinopathy (P = .0008) and idiopathic macular hole (P = .034). For eyes with diabetic retinopathy, the pigment epithelium-derived factor level was 0.88 ± 0.21 μg/ml in proliferative diabetic retinopathy and 2.43 ± 0.37 μg/ml in nonproliferative diabetic retinopathy (P = .0083). Additionally, the pigment epithelium-derived factor level in active diabetic retinopathy (0.70 ± 0.22 μg/ml) was significantly lower than the level in inactive diabetic retinopathy (1.79 ± 0.35 μg/ml; P = .018). CONCLUSIONS: These results suggest that pigment epithelium-derived factor inhibits angiogenesis and that lower levels of pigment epithelium-derived factor may be related to the angiogenesis in diabetic retinopathy and result in active proliferative diabetic retinopathy. The results also suggest that higher levels of pigment epithelium-derived factor in the eyes with rhegmatogenous retinal detachment may act as a neuroprotective agent for the detached retina.",
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Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. / Ogata, Nahoko; Tombran-Tink, Joyce; Nishikawa, Maki; Nishimura, Tetsuya; Mitsuma, Yumiko; Sakamoto, Taiji; Matsumura, Miyo.

In: American Journal of Ophthalmology, Vol. 132, No. 3, 31.08.2001, p. 378-382.

Research output: Contribution to journalArticle

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T1 - Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment

AU - Ogata, Nahoko

AU - Tombran-Tink, Joyce

AU - Nishikawa, Maki

AU - Nishimura, Tetsuya

AU - Mitsuma, Yumiko

AU - Sakamoto, Taiji

AU - Matsumura, Miyo

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N2 - PURPOSE: To report the levels of pigment epithelium-derived factor in the vitreous of patients with diabetic retinopathy, rhegmatogenous retinal detachment, and idiopathic macular hole. METHODS: Using enzyme-linked immunosorbent assay, we measured the levels of pigment epithelium-derived factor in the vitreous of 34 eyes of 33 patients who underwent vitrectomy for the treatment of diabetic retinopathy (17 eyes of 16 patients), rhegmatogenous retinal detachment (10 eyes), and idiopathic macular hole (seven eyes). RESULTS: The vitreal concentration of pigment epithelium-derived factor was 1.15 ± 0.23 μg/ml (mean ± standard error) in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in rhegmatogenous retinal detachment, and 1.71 ± 0.39 μg/ml in idiopathic macular hole. The pigment epithelium-derived factor level in rhegmatogenous retinal detachment was significantly higher than that in diabetic retinopathy (P = .0008) and idiopathic macular hole (P = .034). For eyes with diabetic retinopathy, the pigment epithelium-derived factor level was 0.88 ± 0.21 μg/ml in proliferative diabetic retinopathy and 2.43 ± 0.37 μg/ml in nonproliferative diabetic retinopathy (P = .0083). Additionally, the pigment epithelium-derived factor level in active diabetic retinopathy (0.70 ± 0.22 μg/ml) was significantly lower than the level in inactive diabetic retinopathy (1.79 ± 0.35 μg/ml; P = .018). CONCLUSIONS: These results suggest that pigment epithelium-derived factor inhibits angiogenesis and that lower levels of pigment epithelium-derived factor may be related to the angiogenesis in diabetic retinopathy and result in active proliferative diabetic retinopathy. The results also suggest that higher levels of pigment epithelium-derived factor in the eyes with rhegmatogenous retinal detachment may act as a neuroprotective agent for the detached retina.

AB - PURPOSE: To report the levels of pigment epithelium-derived factor in the vitreous of patients with diabetic retinopathy, rhegmatogenous retinal detachment, and idiopathic macular hole. METHODS: Using enzyme-linked immunosorbent assay, we measured the levels of pigment epithelium-derived factor in the vitreous of 34 eyes of 33 patients who underwent vitrectomy for the treatment of diabetic retinopathy (17 eyes of 16 patients), rhegmatogenous retinal detachment (10 eyes), and idiopathic macular hole (seven eyes). RESULTS: The vitreal concentration of pigment epithelium-derived factor was 1.15 ± 0.23 μg/ml (mean ± standard error) in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in rhegmatogenous retinal detachment, and 1.71 ± 0.39 μg/ml in idiopathic macular hole. The pigment epithelium-derived factor level in rhegmatogenous retinal detachment was significantly higher than that in diabetic retinopathy (P = .0008) and idiopathic macular hole (P = .034). For eyes with diabetic retinopathy, the pigment epithelium-derived factor level was 0.88 ± 0.21 μg/ml in proliferative diabetic retinopathy and 2.43 ± 0.37 μg/ml in nonproliferative diabetic retinopathy (P = .0083). Additionally, the pigment epithelium-derived factor level in active diabetic retinopathy (0.70 ± 0.22 μg/ml) was significantly lower than the level in inactive diabetic retinopathy (1.79 ± 0.35 μg/ml; P = .018). CONCLUSIONS: These results suggest that pigment epithelium-derived factor inhibits angiogenesis and that lower levels of pigment epithelium-derived factor may be related to the angiogenesis in diabetic retinopathy and result in active proliferative diabetic retinopathy. The results also suggest that higher levels of pigment epithelium-derived factor in the eyes with rhegmatogenous retinal detachment may act as a neuroprotective agent for the detached retina.

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