Pimecrolimus Cream 1%

A Potential New Treatment for Chronic Hand Dermatitis

Donald V. Belsito, Joseph F. Fowler, James Marks, David M. Pariser, Jon Hanifin, Ida Alzira Gomes Duarte, Mario C. Pires, Ponciano D. Cruz, Richard G.B. Langley, Premal Patel, Christopher Bush, Mark Thurston, Michael Graeber, Robert Cherill

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

A multicenter, randomized, vehicle-controlled, 3-week study was conducted in patients with chronic hand dermatitis (HD) of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of pimecrolimus cream 1% with overnight occlusion. A total of 294 patients were randomized to the study. By the final visit on day 22, there was a trend toward greater clearance in patients who received pimecrolimus than in those treated with vehicle cream. An analysis of treatment success by various stratification factors was performed, and it was found that palmar involvement had notable impact on response (P = .033). Patients in the pimecrolimus group continued to improve throughout the study; however, in the vehicle group, improvement plateaued after 15 days. Pimecrolimus was well tolerated, with a low rate of application-site reactions such as burning. Pimecrolimus cream 1%, when used twice daily with overnight occlusion, may be of benefit in the management of chronic HD.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalCutis
Volume73
Issue number1
StatePublished - Jan 1 2004

Fingerprint

Dermatitis
Hand
Therapeutics
pimecrolimus

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Belsito, D. V., Fowler, J. F., Marks, J., Pariser, D. M., Hanifin, J., Gomes Duarte, I. A., ... Cherill, R. (2004). Pimecrolimus Cream 1%: A Potential New Treatment for Chronic Hand Dermatitis. Cutis, 73(1), 31-38.
Belsito, Donald V. ; Fowler, Joseph F. ; Marks, James ; Pariser, David M. ; Hanifin, Jon ; Gomes Duarte, Ida Alzira ; Pires, Mario C. ; Cruz, Ponciano D. ; Langley, Richard G.B. ; Patel, Premal ; Bush, Christopher ; Thurston, Mark ; Graeber, Michael ; Cherill, Robert. / Pimecrolimus Cream 1% : A Potential New Treatment for Chronic Hand Dermatitis. In: Cutis. 2004 ; Vol. 73, No. 1. pp. 31-38.
@article{7a1472317ebd493eac061e541d332f92,
title = "Pimecrolimus Cream 1{\%}: A Potential New Treatment for Chronic Hand Dermatitis",
abstract = "A multicenter, randomized, vehicle-controlled, 3-week study was conducted in patients with chronic hand dermatitis (HD) of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of pimecrolimus cream 1{\%} with overnight occlusion. A total of 294 patients were randomized to the study. By the final visit on day 22, there was a trend toward greater clearance in patients who received pimecrolimus than in those treated with vehicle cream. An analysis of treatment success by various stratification factors was performed, and it was found that palmar involvement had notable impact on response (P = .033). Patients in the pimecrolimus group continued to improve throughout the study; however, in the vehicle group, improvement plateaued after 15 days. Pimecrolimus was well tolerated, with a low rate of application-site reactions such as burning. Pimecrolimus cream 1{\%}, when used twice daily with overnight occlusion, may be of benefit in the management of chronic HD.",
author = "Belsito, {Donald V.} and Fowler, {Joseph F.} and James Marks and Pariser, {David M.} and Jon Hanifin and {Gomes Duarte}, {Ida Alzira} and Pires, {Mario C.} and Cruz, {Ponciano D.} and Langley, {Richard G.B.} and Premal Patel and Christopher Bush and Mark Thurston and Michael Graeber and Robert Cherill",
year = "2004",
month = "1",
day = "1",
language = "English (US)",
volume = "73",
pages = "31--38",
journal = "Cutis",
issn = "0011-4162",
publisher = "Quadrant Healthcom Inc.",
number = "1",

}

Belsito, DV, Fowler, JF, Marks, J, Pariser, DM, Hanifin, J, Gomes Duarte, IA, Pires, MC, Cruz, PD, Langley, RGB, Patel, P, Bush, C, Thurston, M, Graeber, M & Cherill, R 2004, 'Pimecrolimus Cream 1%: A Potential New Treatment for Chronic Hand Dermatitis', Cutis, vol. 73, no. 1, pp. 31-38.

Pimecrolimus Cream 1% : A Potential New Treatment for Chronic Hand Dermatitis. / Belsito, Donald V.; Fowler, Joseph F.; Marks, James; Pariser, David M.; Hanifin, Jon; Gomes Duarte, Ida Alzira; Pires, Mario C.; Cruz, Ponciano D.; Langley, Richard G.B.; Patel, Premal; Bush, Christopher; Thurston, Mark; Graeber, Michael; Cherill, Robert.

In: Cutis, Vol. 73, No. 1, 01.01.2004, p. 31-38.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pimecrolimus Cream 1%

T2 - A Potential New Treatment for Chronic Hand Dermatitis

AU - Belsito, Donald V.

AU - Fowler, Joseph F.

AU - Marks, James

AU - Pariser, David M.

AU - Hanifin, Jon

AU - Gomes Duarte, Ida Alzira

AU - Pires, Mario C.

AU - Cruz, Ponciano D.

AU - Langley, Richard G.B.

AU - Patel, Premal

AU - Bush, Christopher

AU - Thurston, Mark

AU - Graeber, Michael

AU - Cherill, Robert

PY - 2004/1/1

Y1 - 2004/1/1

N2 - A multicenter, randomized, vehicle-controlled, 3-week study was conducted in patients with chronic hand dermatitis (HD) of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of pimecrolimus cream 1% with overnight occlusion. A total of 294 patients were randomized to the study. By the final visit on day 22, there was a trend toward greater clearance in patients who received pimecrolimus than in those treated with vehicle cream. An analysis of treatment success by various stratification factors was performed, and it was found that palmar involvement had notable impact on response (P = .033). Patients in the pimecrolimus group continued to improve throughout the study; however, in the vehicle group, improvement plateaued after 15 days. Pimecrolimus was well tolerated, with a low rate of application-site reactions such as burning. Pimecrolimus cream 1%, when used twice daily with overnight occlusion, may be of benefit in the management of chronic HD.

AB - A multicenter, randomized, vehicle-controlled, 3-week study was conducted in patients with chronic hand dermatitis (HD) of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of pimecrolimus cream 1% with overnight occlusion. A total of 294 patients were randomized to the study. By the final visit on day 22, there was a trend toward greater clearance in patients who received pimecrolimus than in those treated with vehicle cream. An analysis of treatment success by various stratification factors was performed, and it was found that palmar involvement had notable impact on response (P = .033). Patients in the pimecrolimus group continued to improve throughout the study; however, in the vehicle group, improvement plateaued after 15 days. Pimecrolimus was well tolerated, with a low rate of application-site reactions such as burning. Pimecrolimus cream 1%, when used twice daily with overnight occlusion, may be of benefit in the management of chronic HD.

UR - http://www.scopus.com/inward/record.url?scp=10744225363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744225363&partnerID=8YFLogxK

M3 - Article

VL - 73

SP - 31

EP - 38

JO - Cutis

JF - Cutis

SN - 0011-4162

IS - 1

ER -

Belsito DV, Fowler JF, Marks J, Pariser DM, Hanifin J, Gomes Duarte IA et al. Pimecrolimus Cream 1%: A Potential New Treatment for Chronic Hand Dermatitis. Cutis. 2004 Jan 1;73(1):31-38.