Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

Jidong Fang, Linda Payne, James M. Krueger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalBrain research
Volume686
Issue number1
DOIs
StatePublished - Jul 17 1995

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
REM Sleep
Sleep
Light
Vasoactive Intestinal Peptide
Eye Movements
Sprague Dawley Rats
Injections
Temperature
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Fang, Jidong ; Payne, Linda ; Krueger, James M. / Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats. In: Brain research. 1995 ; Vol. 686, No. 1. pp. 23-28.
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Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats. / Fang, Jidong; Payne, Linda; Krueger, James M.

In: Brain research, Vol. 686, No. 1, 17.07.1995, p. 23-28.

Research output: Contribution to journalArticle

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