Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

Jidong Fang, Linda Payne, James M. Krueger

Research output: Contribution to journalArticle

28 Scopus citations


Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalBrain research
Issue number1
StatePublished - Jul 17 1995


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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