Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse

D. Jeffrey Newport, Christine Marcelle Heim, Robert Bonsall, Andrew H. Miller, Charles B. Nemeroff

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Background: Previous studies indicate that adverse childhood events are associated with persistent changes in corticotropin-releasing factor neuronal systems. Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma. Methods: Standard and low-dose dexamethasone suppression tests (DST) were performed in women with a history of child abuse (n = 19), child abuse and major depression (n = 16), major depression and no childhood trauma (n = 10), and no history of mental illness or childhood trauma (n = 19). Secondary analysis with posttraumatic stress disorder (PTSD) as the organizing diagnosis was also conducted. Results: In the low-dose DST, depressed women with a history of abuse exhibited greater cortisol suppression than any comparator group and greater corticotropin suppression than healthy volunteers or nondepressed abuse survivors. There were no differences between nondepressed abuse survivors and healthy volunteers in the low-dose DST or between any subject groups in the standard DST. The PTSD analysis produced similar results. Conclusions: Cortisol supersuppression is evident in psychiatrically ill trauma survivors, but not in nondepressed abuse survivors, indicating that enhanced glucocorticoid feedback is not an invariable consequence of childhood trauma but is more related to the resultant psychiatric illness in traumatized individuals.

Original languageEnglish (US)
Pages (from-to)10-20
Number of pages11
JournalBiological Psychiatry
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2004

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Adult Survivors of Child Abuse
Dexamethasone
Survivors
Wounds and Injuries
Child Abuse
Post-Traumatic Stress Disorders
Glucocorticoids
Hydrocortisone
Healthy Volunteers
Depression
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Psychiatry

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

Newport, D. Jeffrey ; Heim, Christine Marcelle ; Bonsall, Robert ; Miller, Andrew H. ; Nemeroff, Charles B. / Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. In: Biological Psychiatry. 2004 ; Vol. 55, No. 1. pp. 10-20.
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Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. / Newport, D. Jeffrey; Heim, Christine Marcelle; Bonsall, Robert; Miller, Andrew H.; Nemeroff, Charles B.

In: Biological Psychiatry, Vol. 55, No. 1, 01.01.2004, p. 10-20.

Research output: Contribution to journalArticle

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