PKR and the ribosome compete for mRNA

Rebecca Toroney, Philip C. Bevilacqua

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

Original languageEnglish (US)
Pages (from-to)873-874
Number of pages2
JournalNature Chemical Biology
Volume5
Issue number12
DOIs
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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