PKR and the ribosome compete for mRNA

Rebecca Toroney, Philip C. Bevilacqua

Research output: Contribution to journalShort survey

4 Citations (Scopus)

Abstract

The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

Original languageEnglish (US)
Pages (from-to)873-874
Number of pages2
JournalNature Chemical Biology
Volume5
Issue number12
DOIs
StatePublished - Jan 1 2009

Fingerprint

eIF-2 Kinase
Ribosomes
Messenger RNA
Double-Stranded RNA
Viral RNA

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Toroney, Rebecca ; Bevilacqua, Philip C. / PKR and the ribosome compete for mRNA. In: Nature Chemical Biology. 2009 ; Vol. 5, No. 12. pp. 873-874.
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PKR and the ribosome compete for mRNA. / Toroney, Rebecca; Bevilacqua, Philip C.

In: Nature Chemical Biology, Vol. 5, No. 12, 01.01.2009, p. 873-874.

Research output: Contribution to journalShort survey

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