Placental prostaglandin levels in pre-eclampsia

Laurence Demers, Steven G. Gabbe

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume126
Issue number1
DOIs
StatePublished - Sep 1 1976

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Pre-Eclampsia
Prostaglandins
Prostaglandins F
Vasoconstrictor Agents
Prostaglandins E
Ischemia
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Demers, Laurence ; Gabbe, Steven G. / Placental prostaglandin levels in pre-eclampsia. In: American Journal of Obstetrics and Gynecology. 1976 ; Vol. 126, No. 1. pp. 137-139.
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Placental prostaglandin levels in pre-eclampsia. / Demers, Laurence; Gabbe, Steven G.

In: American Journal of Obstetrics and Gynecology, Vol. 126, No. 1, 01.09.1976, p. 137-139.

Research output: Contribution to journalArticle

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