Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade

Dong Lei Yang, Jian Yao, Chuan Sheng Mei, Xiao Hong Tong, Long Jun Zeng, Qun Li, Lang Tao Xiao, Tai Ping Sun, Jigang Li, Xing Wang Deng, Chin Mei Lee, Michael F. Thomashow, Yinong Yang, Zuhua He, Sheng Yang He

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398 Scopus citations

Abstract

Plants must effectively defend against biotic and abiotic stresses to survive in nature. However, this defense is costly and is often accompanied by significant growth inhibition. How plants coordinate the fluctuating growth-defense dynamics is not well understood and remains a fundamental question. Jasmonate (JA) and gibberellic acid (GA) are important plant hormones that mediate defense and growth, respectively. Binding of bioactive JA or GA ligands to cognate receptors leads to proteasome-dependent degradation of specific transcriptional repressors (the JAZ or DELLA family of proteins), which, at the resting state, represses cognate transcription factors involved in defense (e.g., MYCs) or growth [e.g. phytochrome interacting factors (PIFs)]. In this study, we found that the coi1 JA receptor mutants of rice (a domesticated monocot crop) and Arabidopsis (a model dicot plant) both exhibit hallmark phenotypes of GA-hypersensitive mutants. JA delays GA-mediated DELLA protein degradation, and the della mutant is less sensitive to JA for growth inhibition. Overexpression of a selected group of JAZ repressors in Arabidopsis plants partially phenocopies GA-associated phenotypes of the coi1 mutant, and JAZ9 inhibits RGA (a DELLA protein) interaction with transcription factor PIF3. Importantly, the pif quadruple (pifq) mutant no longer responds to JA-induced growth inhibition, and overexpression of PIF3 could partially overcome JA-induced growth inhibition. Thus, a molecular cascade involving the COI1-JAZ-DELLA-PIF signaling module, by which angiosperm plants prioritize JA-mediated defense over growth, has been elucidated.

Original languageEnglish (US)
Pages (from-to)E1192-E1200
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number19
DOIs
StatePublished - May 8 2012

All Science Journal Classification (ASJC) codes

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    Yang, D. L., Yao, J., Mei, C. S., Tong, X. H., Zeng, L. J., Li, Q., Xiao, L. T., Sun, T. P., Li, J., Deng, X. W., Lee, C. M., Thomashow, M. F., Yang, Y., He, Z., & He, S. Y. (2012). Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade. Proceedings of the National Academy of Sciences of the United States of America, 109(19), E1192-E1200. https://doi.org/10.1073/pnas.1201616109