Plant protein and animal proteins: Do they differentially affect cardiovascular disease risk?

Chesney K. Richter, Ann C. Skulas-Ray, Catherine M. Champagne, Penny Margaret Kris-Etherton

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Proteins from plant-based compared with animal-based food sources may have different effects on cardiovascular disease (CVD) risk factors. Numerous epidemiologic and intervention studies have evaluated their respective health benefits; however, it is difficult to isolate the role of plant or animal protein on CVD risk. This review evaluates the current evidence from observational and intervention studies, focusing on the specific protein-providing foods and populations studied. Dietary protein is derived from many food sources, and each provides a different composite of nonprotein compounds that can also affect CVD risk factors. Increasing the consumption of protein-rich foods also typically results in lower intakes of other nutrients, which may simultaneously influence outcomes. Given these complexities, blanket statements about plant or animal protein may be too general, and greater consideration of the specific protein food sources and the background diet is required. The potential mechanisms responsible for any specific effects of plant and animal protein are similarly multifaceted and include the amino acid content of particular foods, contributions from other nonprotein compounds provided concomitantly by the whole food, and interactions with the gut microbiome. Evidence to date is inconclusive, and additional studies are needed to further advance our understanding of the complexity of plant protein vs. animal protein comparisons. Nonetheless, current evidence supports the idea that CVD risk can be reduced by a dietary pattern that provides more plant sources of protein compared with the typical American diet and also includes animal-based protein foods that are unprocessed and low in saturated fat.

Original languageEnglish (US)
Pages (from-to)712-728
Number of pages17
JournalAdvances in Nutrition
Volume6
Issue number6
DOIs
StatePublished - Jan 1 2015

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Plant Proteins
animal proteins
plant proteins
cardiovascular diseases
Cardiovascular Diseases
protein sources
Food
Proteins
risk factors
plant source protein
animal-based foods
eating habits
nutrient intake
diet
dietary protein
proteins
digestive system
Food-Drug Interactions
Diet
amino acids

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Richter, Chesney K. ; Skulas-Ray, Ann C. ; Champagne, Catherine M. ; Kris-Etherton, Penny Margaret. / Plant protein and animal proteins : Do they differentially affect cardiovascular disease risk?. In: Advances in Nutrition. 2015 ; Vol. 6, No. 6. pp. 712-728.
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Plant protein and animal proteins : Do they differentially affect cardiovascular disease risk? / Richter, Chesney K.; Skulas-Ray, Ann C.; Champagne, Catherine M.; Kris-Etherton, Penny Margaret.

In: Advances in Nutrition, Vol. 6, No. 6, 01.01.2015, p. 712-728.

Research output: Contribution to journalReview article

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