Plasma 6 keto PGF1α concentration in Raynaud's phenomenon

Evlin L. Kinney, Laurence M. Demers

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To examine the possibility that prostaglandin metabolism is pathophysiologically important in Raynaud's phenomenon, peripheral venous 6-keto prostaglandin Fla (6-keto PGF1α) and thromboxane B2 (TXB2) concentrations were measured in 45 patients with severe Raynaud's phenomenon. Patients with Raynaud's phenomenon had a significantly higher plasma concentration of 6-keto PGF1α compared to controls (p < .001), although their plasma TXB2 concentration was not statistically different from control patients. Subgroup analysis revealed that only patients with progressive systemic sclerosis (PSS) had an elevated plasma 6-keto PGF1α concentration. To gauge the functional significance of the 6-keto PGF1α elevations, seven patients with Raynaud's phenomenon were chronically administered indomethacin (50 mg P.O. b.i.d.); six of the seven patients noted no improvement in their Raynaud's phenomenon. Three of the patients developed pedal edema shortly after starting indomethacin. This study suggests that the increased plasma 6-keto PGF1α concentration in Raynaud's phenomenon may be due to a compensatory release of prostacyclin and that the pathophysiologic defect does not involve the thromboxane mechanism.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalProstaglandines and Medicine
Volume7
Issue number5
DOIs
StatePublished - Nov 1981

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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