Plasma biomarkers associated with ALS and their relationship to iron homeostasis

Ryan M. Mitchell, Zachary Simmons, John L. Beard, Helen E. Stephens, James R. Connor

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis with variable presentation and disease progression. There is a critical need for a panel of biomarkers to provide clinicians and researchers with additional information. In this study, multiplex immunoassays were used to screen a number of cytokines, growth factors, and iron-related proteins. ALS patients had significantly higher plasma levels of L-ferritin and lower concentrations of transferrin when compared to healthy controls and together classified a test group of subjects with 82% accuracy. Duration of ALS symptoms correlated positively with levels of monocyte chemoattractant protein 1 (MCP-1) and negatively with levels of granulocyte-macrophage colony stimulating factor (GM-CSF). The biomarker profile suggests iron homeostasis is disrupted in ALS patients, and changes in ferritin and transferrin (Tf) appear to be indicators of ongoing inflammatory processes. The data demonstrate a plasma biomarker profile in ALS patients that may differ from published reports of cerebrospinal fluid biomarkers.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalMuscle and Nerve
Volume42
Issue number1
DOIs
StatePublished - Jul 1 2010

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Plasma biomarkers associated with ALS and their relationship to iron homeostasis'. Together they form a unique fingerprint.

Cite this