Plasma calcitonin activity in a patient with thyroid medullary carcinoma and her children with osteopetrosis

M. Verdy, R. Beaulieu, L. Demers, W. C. Sturtridge, P. Thomas, M. Ashwini Kumar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Plasma calcitonin was measured in a 38-yr-old female patient with metastatic carcinoma of the thyroid, 3 yr after total thyroidectomy. There was a diffuse increase in skeletal density as well as an elevation in plasma calcitonin concentration. This patient had 11 pregnancies with 9 live births. At least 4 of the 9 children are believed to have had osteopetrosis. Two of the 4 have died but plasma calcitonin activity was measured in the 2 surviving children and was not found to be elevated. A relationship between circulating calcitonin excess and osteopetrosis cannot be substantiated. A genetic relationship between medullary carcinoma and osteopetrosis deserves investigation.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume32
Issue number2
DOIs
StatePublished - Jan 1 1971

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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