Plasma coagulation response to surfaces with nanoscale chemical heterogeneity

Rachel Miller, Zhe Guo, Erwin A. Vogler, Christopher Siedlecki

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A mixed film bearing nanoscale domains of one chemical functionality surrounded by another chemical functionality is shown to prolong material-induced coagulation of whole human blood plasma. In comparison, surfaces with uniform silane chemistry or physical mixtures of control surfaces bearing two different, uniform silane chemistries are found to be much more efficient activators of plasma coagulation on a per-unit-area basis. Binary mixed films are deposited on glass substrates by the sequential adsorption of 0.0001% 3-aminopropyltriethoxysilane (APS) followed by 0.1% n- butyltrichlorosilane (BTS). Creation of APS islands in a sea of BTS is confirmed by atomic force microscopy in friction mode. Results suggest that some yet-to-be-determined interfacial phenomena, perhaps associated with protein adsorption near the interface, may be altered by this nanoscale spatially distributed chemical heterogeneity, causing a decrease in contact activation.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalBiomaterials
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2006

Fingerprint

Silanes
Bearings (structural)
Coagulation
Adsorption
Physical Chemistry
Plasmas
Friction
Atomic Force Microscopy
Islands
Glass
Control surfaces
Atomic force microscopy
Blood
Chemical activation
Proteins
Substrates
gamma-aminopropyltriethoxysilane

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Miller, Rachel ; Guo, Zhe ; Vogler, Erwin A. ; Siedlecki, Christopher. / Plasma coagulation response to surfaces with nanoscale chemical heterogeneity. In: Biomaterials. 2006 ; Vol. 27, No. 2. pp. 208-215.
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Plasma coagulation response to surfaces with nanoscale chemical heterogeneity. / Miller, Rachel; Guo, Zhe; Vogler, Erwin A.; Siedlecki, Christopher.

In: Biomaterials, Vol. 27, No. 2, 01.01.2006, p. 208-215.

Research output: Contribution to journalArticle

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